Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
| ▸ | PTGES | O14684 | 1/20 | 0.32 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.31 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.31 |
| ▸ | PGR | P06401 | 1/20 | 0.31 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.31 |
| ▸ | OGA | O60502 | 1/20 | 0.30 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14189080 | 0.77 | PARP1 (0.54) | PARP1PTGS1PTGS2CYP2A6NR3C1 | |
| SCHEMBL8011587 | 0.76 | PARP1 (0.37) | PARP1PTGS1PTGS2RAPGEF4CYP2A6 | |
| SCHEMBL13629595 | 0.76 | PTGS1 (0.39) | PARP1PTGS1PTGS2CYP2A6 | |
| SCHEMBL31172611 | 0.74 | MAPT (0.36) | MAPTNPSR1RXFP1PARP1 | |
| SCHEMBL31172619 | 0.74 | PARP1 (0.38) | MAPTNPSR1RXFP1PARP1PTGS1 | |
| SCHEMBL5542428 | 0.73 | PARP1 (0.39) | PARP1PTGS1PTGS2CYP2A6 | |
| SCHEMBL6342164 | 0.73 | MAPT (0.36) | MAPTNPSR1RXFP1PARP1PTGS1 | |
| SCHEMBL8466298 | 0.73 | PARP1 (0.39) | PARP1PTGS1PTGS2CYP2A6 | |
| SCHEMBL31394015 | 0.73 | MAPT (0.36) | MAPTNPSR1RXFP1PARP1PTGS1 | |
| SCHEMBL7484709 | 0.73 | PARP1 (0.39) | PARP1PTGS1PTGS2CYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022109001-A1 | GCN2 AND PERK KINASE INHIBITORS AND METHODS OF USE THEREOF | DECIPHERA PHARMACEUTICALS, LLC (US) | 2022-05-27 | — | — | WO | disclosed |
| US-7622487-B2 | Piperidine derivative, process for producing the same, and use | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-11-24 | — | — | US | disclosed |
| US-7622487-B2 | Piperidine derivative, process for producing the same, and use | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-11-24 | — | — | US | disclosed |