Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.69 |
| ▸ | RAB9A | P51151 | 4/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.55 |
| ▸ | MEN1 | O00255 | 6/20 | 0.55 |
| ▸ | MAPT | P10636 | 5/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.52 |
| ▸ | IDE | P14735 | 1/20 | 0.52 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13629846 | 0.85 | NPC1 (0.56) | NPC1RAB9AALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL13630095 | 0.85 | NPC1 (0.56) | NPC1RAB9AALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL13616378 | 0.84 | NPC1 (0.64) | NPC1RAB9AALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL13616326 | 0.84 | NPC1 (0.64) | NPC1RAB9AALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL13616318 | 0.84 | NPC1 (0.73) | NPC1RAB9AALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL13616384 | 0.83 | NPC1 (0.61) | NPC1RAB9AALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL4352450 | 0.81 | SENP1 (0.78) | NPC1RAB9AALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL13616352 | 0.81 | NPC1 (0.73) | NPC1RAB9AALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL13616339 | 0.81 | NPC1 (1.00) | NPC1RAB9AALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL4352447 | 0.81 | SENP1 (0.78) | NPC1RAB9AALDH1A1SMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090275538-A1 | ARYLMETHYLIDENE HETEROCYCLES AS NOVEL ANALGESICS | UNIVERSITE LAVAL (CA) | 2009-11-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090275538-A1 | ARYLMETHYLIDENE HETEROCYCLES AS NOVEL ANALGESICS | OPRL1, OPRK1, AHR | NPC1 2712/4885RAB9A 4212/4885ALDH1A1 211/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.