Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACKR3 | P25106 | 1/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 5/20 | 0.35 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | CDK9 | P50750 | 1/20 | 0.31 |
| ▸ | KAT8 | Q9H7Z6 | 2/20 | 0.31 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.31 |
| ▸ | SLC6A5 | Q9Y345 | 2/20 | 0.31 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.30 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.30 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.30 |
| ▸ | GBA1 | P04062 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2436462 | 0.89 | NR1I2 (0.37) | ACKR3S1PR1SMYD3GSK3BDYRK1A | |
| SCHEMBL12328894 | 0.89 | ACKR3 (0.37) | ACKR3S1PR1SMYD3GSK3BDYRK1A | |
| SCHEMBL2436465 | 0.89 | NR1I2 (0.37) | ACKR3S1PR1SMYD3GSK3BDYRK1A | |
| SCHEMBL2429880 | 0.88 | ACKR3 (0.36) | ACKR3S1PR1SMYD3GSK3BDYRK1A | |
| SCHEMBL2429886 | 0.88 | ACKR3 (0.36) | ACKR3S1PR1SMYD3GSK3BDYRK1A | |
| SCHEMBL13630804 | 0.86 | ALDH1A1 (0.38) | ACKR3S1PR1SMYD3GSK3BDYRK1A | |
| SCHEMBL13630757 | 0.84 | S1PR1 (0.31) | S1PR1 | |
| SCHEMBL13630758 | 0.84 | ACKR3 (0.34) | ACKR3S1PR1SMYD3CDK9SLC6A9 | |
| SCHEMBL13630690 | 0.79 | GRM4 (0.33) | GRM4 | |
| SCHEMBL2430873 | 0.79 | ACKR3 (0.38) | ACKR3SMYD3CDK9KAT8SLC6A9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090274655-A1 | 2-CARBOXY THIOPHENE DERIVATIVES AS ANTI VIRAL AGENTS | SMITHKLINE BEECHAM CORPORATION | 2009-11-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090274655-A1 | 2-CARBOXY THIOPHENE DERIVATIVES AS ANTI VIRAL AGENTS | EIF2AK2, HAVCR2, GTF3C2 | ACKR3 3377/4885S1PR1 2888/4885SMYD3 3068/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.