Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 5/20 | 0.52 |
| ▸ | CDC7 | O00311 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.40 |
| ▸ | CHUK | O15111 | 2/20 | 0.38 |
| ▸ | INSR | P06213 | 2/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.38 |
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | TNF | P01375 | 1/20 | 0.36 |
| ▸ | RAD52 | P43351 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | PYGL | P06737 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2197115 | 0.88 | ADORA3 (0.44) | BRD4CDC7ALDH1A1KDM4E | |
| SCHEMBL12509464 | 0.88 | MAPK8 (0.43) | BRD4CDC7JAK2ALDH1A1CHUK | |
| SCHEMBL2197511 | 0.86 | BRD4 (0.46) | BRD4CDC7CHUKINSRMAPK8 | |
| SCHEMBL2200930 | 0.86 | JAK2 (0.52) | BRD4JAK2ALDH1A1MEN1KMT2A | |
| SCHEMBL2196927 | 0.85 | CDC7 (0.54) | BRD4CDC7ALDH1A1CHUKINSR | |
| SCHEMBL12509465 | 0.84 | CDC7 (0.42) | BRD4CDC7JAK2CHUKINSR | |
| SCHEMBL13630074 | 0.84 | BRD4 (0.56) | BRD4CDC7JAK2ALDH1A1KDM4C | |
| SCHEMBL2200384 | 0.82 | MEN1 (0.45) | ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL12509581 | 0.82 | BRD4 (0.38) | BRD4CDC7JAK2CHUKINSR | |
| SCHEMBL13630719 | 0.80 | BRD4 (0.42) | BRD4CDC7ALDH1A1CHUKINSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2116530-A1 | NOVEL PYRROLE DERIVATIVE HAVING UREIDE GROUP AND AMINOCARBONYL GROUP AS SUBSTITUENTS | Santen Pharmaceutical Co., Ltd (JP) | 2009-11-11 | — | — | EP | disclosed |