Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | F10 | P00742 | 5/20 | 0.41 |
| ▸ | BACE1 | P56817 | 2/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13632167 | 0.92 | F10 (0.47) | TP53LMNAKDM4EMAPTF10 | |
| SCHEMBL4492429 | 0.85 | LMNA (0.50) | TP53LMNAF10ENPP2 | |
| SCHEMBL4560255 | 0.84 | TP53 (0.48) | TP53LMNAF10ENPP2 | |
| SCHEMBL4505697 | 0.84 | LMNA (0.48) | TP53LMNAMAPTF10ENPP2 | |
| SCHEMBL4501332 | 0.81 | F10 (0.53) | TP53LMNAF10ENPP2 | |
| SCHEMBL4492374 | 0.81 | F10 (0.52) | TP53LMNAF10ENPP2 | |
| SCHEMBL4500589 | 0.81 | LMNA (0.46) | TP53LMNAF10ENPP2 | |
| SCHEMBL4490933 | 0.79 | F10 (0.57) | TP53LMNAF10ENPP2 | |
| SCHEMBL4500425 | 0.79 | LMNA (0.46) | TP53LMNAF10ENPP2 | |
| SCHEMBL4495243 | 0.79 | TP53 (0.45) | TP53LMNAF10ENPP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7615549-B2 | Substituted pyrrolidinones, their manufacture and their use as medicaments | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-11-10 | — | — | US | disclosed |
| US-7615549-B2 | Substituted pyrrolidinones, their manufacture and their use as medicaments | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-11-10 | — | — | US | disclosed |