Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 13/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13632168 | 0.92 | TP53 (0.44) | F10TP53LMNAKDM4EMAPT | |
| SCHEMBL4505024 | 0.85 | F10 (0.54) | F10TP53LMNA | |
| SCHEMBL4496530 | 0.83 | F10 (0.56) | F10TP53LMNA | |
| SCHEMBL4506998 | 0.80 | F10 (0.53) | F10TP53LMNA | |
| SCHEMBL4492540 | 0.80 | F10 (0.62) | F10TP53LMNA | |
| SCHEMBL4506177 | 0.79 | F10 (0.54) | F10TP53LMNA | |
| SCHEMBL4506434 | 0.79 | F10 (0.57) | F10 | |
| SCHEMBL4504908 | 0.78 | F10 (0.53) | F10TP53LMNA | |
| SCHEMBL13632170 | 0.76 | F10 (0.46) | F10LMNAMAPT | |
| SCHEMBL4492429 | 0.76 | LMNA (0.50) | F10TP53LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7615549-B2 | Substituted pyrrolidinones, their manufacture and their use as medicaments | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-11-10 | — | — | US | disclosed |
| US-7615549-B2 | Substituted pyrrolidinones, their manufacture and their use as medicaments | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-11-10 | — | — | US | disclosed |