Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | F10 | P00742 | 4/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | ENPP2 | Q13822 | 7/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13632184 | 0.89 | F10 (0.59) | LMNATP53F10ENPP2 | |
| SCHEMBL13632186 | 0.87 | LMNA (0.46) | LMNATP53F10ENPP2 | |
| SCHEMBL13632176 | 0.85 | TP53 (0.45) | LMNATP53F10TDP1ALDH1A1 | |
| SCHEMBL4505693 | 0.83 | F10 (0.61) | LMNATP53F10ALDH1A1HPGD | |
| SCHEMBL4510420 | 0.82 | F10 (0.52) | LMNATP53F10ALDH1A1HPGD | |
| SCHEMBL3285554 | 0.82 | LMNA (0.50) | LMNATP53F10ALDH1A1HPGD | |
| SCHEMBL4509586 | 0.79 | LMNA (0.49) | LMNATP53F10ALDH1A1HPGD | |
| SCHEMBL4504656 | 0.78 | F10 (0.64) | LMNATP53F10TDP1ALDH1A1 | |
| SCHEMBL4492429 | 0.77 | LMNA (0.50) | LMNATP53F10ALDH1A1HPGD | |
| SCHEMBL4508917 | 0.77 | F10 (0.53) | LMNATP53F10TDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7615549-B2 | Substituted pyrrolidinones, their manufacture and their use as medicaments | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-11-10 | — | — | US | disclosed |
| US-7615549-B2 | Substituted pyrrolidinones, their manufacture and their use as medicaments | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-11-10 | — | — | US | disclosed |