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SCHEMBL13632186

SCHEMBL13632186

C#Cc1ccc(C(=O)N[C@@H]2CC(=O)N(c3ccc(N4CCCCS4(=O)=O)cc3)C2)s1

nearest known ligand 0.46

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 7/20 0.46
▸ TP53 P04637 3/20 0.46
▸ F10 P00742 1/20 0.45
▸ ENPP2 Q13822 7/20 0.42
▸ MAPT P10636 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13632184 0.87 F10 (0.59) LMNATP53F10ENPP2
SCHEMBL13632185 0.87 LMNA (0.50) LMNATP53F10ENPP2
SCHEMBL4503744 0.85 F10 (0.49) LMNATP53F10ENPP2MAPT
SCHEMBL4509943 0.80 TP53 (0.48) LMNATP53F10ENPP2MAPT
SCHEMBL13632166 0.79 LMNA (0.48) LMNATP53F10ENPP2
SCHEMBL5469178 0.78 TP53 (0.45) LMNATP53ENPP2
SCHEMBL3293115 0.77 LMNA (0.51) LMNATP53F10MAPT
SCHEMBL4505244 0.76 LMNA (0.44) LMNATP53F10ENPP2
SCHEMBL13632177 0.76 TP53 (0.46) LMNATP53F10
SCHEMBL4492812 0.74 TP53 (0.44) LMNATP53F10ENPP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7615549-B2 Substituted pyrrolidinones, their manufacture and their use as medicaments BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2009-11-10 — — US disclosed
US-7615549-B2 Substituted pyrrolidinones, their manufacture and their use as medicaments BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2009-11-10 — — US disclosed