Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 9/20 | 0.80 |
| ▸ | GRIN2B | Q13224 | 9/20 | 0.80 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.80 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.71 |
| ▸ | TP53 | P04637 | 1/20 | 0.71 |
| ▸ | MAPT | P10636 | 1/20 | 0.71 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.68 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.68 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.68 |
| ▸ | GPBAR1 | Q8TDU6 | 4/20 | 0.65 |
| ▸ | LMNA | P02545 | 3/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.65 |
| ▸ | SHBG | P04278 | 2/20 | 0.65 |
| ▸ | SERPINA6 | P08185 | 2/20 | 0.65 |
| ▸ | MEN1 | O00255 | 2/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.65 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.65 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.65 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.65 |
| ▸ | G6PD | P11413 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17006954 | 1.00 | GRIN1 (0.80) | GRIN1GRIN2BMAPK1ALDH1A1TP53 | |
| SCHEMBL30421845 | 1.00 | GRIN1 (0.80) | GRIN1GRIN2BMAPK1ALDH1A1TP53 | |
| SCHEMBL235684 | 1.00 | GRIN1 (0.80) | GRIN1GRIN2BMAPK1ALDH1A1TP53 | |
| SCHEMBL235685 | 1.00 | GRIN1 (0.80) | GRIN1GRIN2BMAPK1ALDH1A1TP53 | |
| SCHEMBL7869703 | 1.00 | GRIN1 (0.80) | GRIN1GRIN2BMAPK1ALDH1A1TP53 | |
| SCHEMBL17006955 | 1.00 | GRIN1 (0.80) | GRIN1GRIN2BMAPK1ALDH1A1TP53 | |
| SCHEMBL8581388 | 1.00 | GRIN1 (0.80) | GRIN1GRIN2BMAPK1ALDH1A1TP53 | |
| SCHEMBL332917 | 1.00 | GRIN1 (0.80) | GRIN1GRIN2BMAPK1ALDH1A1TP53 | |
| SCHEMBL2079281 | 1.00 | GRIN1 (0.80) | GRIN1GRIN2BMAPK1ALDH1A1TP53 | |
| SCHEMBL136324 | 1.00 | GRIN1 (0.80) | GRIN1GRIN2BMAPK1ALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 143 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250199014-A1 | METABOLITE BIOMARKERS FOR DISEASES ASSOCIATED WITH THE CONTACT ACTIVATION SYSTEM | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2025-06-19 | — | — | US | claimed |
| CN-119517408-A | Method for establishing death prediction model of new-onset type 2 diabetes and application | 中南大学湘雅二医院 | 2025-02-25 | — | — | CN | claimed |
| CN-115128257-B | Metabolism marker for predicting liver cancer incidence risk and application thereof | 南京医科大学 | 2025-02-18 | — | — | CN | claimed |
| US-12188948-B2 | Metabolite biomarkers for diseases associated with the contact activation system | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2025-01-07 | — | — | US | claimed |
| CN-109716137-B | Metabolite biomarkers for diseases associated with contact activation systems | 武田药品工业株式会社 | 2023-07-21 | — | — | CN | claimed |
| CN-116381073-A | Application of biomarker in preparation of lung cancer detection reagent and method | 中山大学肿瘤防治中心（中山大学附属肿瘤医院、中山大学肿瘤研究所） | 2023-07-04 | — | — | CN | claimed |
| US-20230194554-A1 | USE OF BIOMARKER IN PREPARATION OF LUNG CANCER DETECTION REAGENT AND RELATED METHOD | SUN YAT-SEN UNIVERSITY CANCER CENTER (THE AFFILIATED CANCER HOSPITAL OF SUN YAT-SEN UNIVERSITY, THE CANCER RESEARCH INSTITUTE OF SUN YAT-SEN UNIVERSITY) (CN) | 2023-06-22 | — | — | US | claimed |
| WO-2023083020-A1 | USE OF SERUM METABOLIC MARKER FOR DETECTING EGFR MUTATION AND DETECTION SYSTEM | 中山大学肿瘤防治中心（中山大学附属肿瘤医院、中山大学肿瘤研究所） | 2023-05-19 | — | — | WO | claimed |
| CN-115575553-A | Application of serum metabolic marker as EGFR mutation detection and detection system | 中山大学肿瘤防治中心（中山大学附属肿瘤医院、中山大学肿瘤研究所） | 2023-01-06 | — | — | CN | claimed |
| US-20220365101-A1 | METABOLITE BIOMARKERS FOR DISEASES ASSOCIATED WITH THE CONTACT ACTIVATION SYSTEM | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2022-11-17 | — | — | US | claimed |
| EP-3129909-A1 | SMALL MOLECULE BIOCHEMICAL PROFILING OF INDIVIDUAL SUBJECTS FOR DISEASE DIAGNOSIS AND HEALTH ASSESSMENT | Metabolon, Inc. (US) | 2017-02-15 | — | — | EP | claimed |
| WO-2015157407-A1 | SMALL MOLECULE BIOCHEMICAL PROFILING OF INDIVIDUAL SUBJECTS FOR DISEASE DIAGNOSIS AND HEALTH ASSESSMENT | METABOLON, INC. (US) | 2015-10-15 | — | — | WO | claimed |
| US-20100273207-A1 | Methods for Diagnosis of Sepsis and Risk of Death | LANGLEY RAYMOND | 2010-10-28 | — | — | US | claimed |
| WO-2010124269-A1 | METHODS FOR DIAGNOSIS OF SEPSIS AND RISK OF DEATH | NATIONAL CENTER FOR GENOME RESOURCES (US) | 2010-10-28 | — | — | WO | claimed |
| EP-1555025-A2 | Use of dehydroepiandrosterone analogs for the treatment of asthma | EAST CAROLINA UNIVERSITY (US) | 2005-07-20 | — | — | EP | claimed |
| JP-2002522389-A | — | — | 2002-07-23 | — | — | JP | claimed |
| EP-1102590-A1 | USE OF A NK-1 RECEPTOR ANTAGONIST FOR TREATING OR PREVENTING ABNORMAL BONE RESORPTION | MERCK SHARP & DOHME LTD. (GB) | 2001-05-30 | — | — | EP | claimed |
| WO-2000007598-A1 | USE OF A NK-1 RECEPTOR ANTAGONIST FOR TREATING OR PREVENTING ABNORMAL BONE RESORPTION | MERCK SHARP & DOHME LIMITED (GB) | 2000-02-17 | — | — | WO | claimed |
| EP-0977576-A1 | OSTEOBLAST-PROMOTING PHARMACEUTICAL COMPOSITION COMPRISING A CARNITINE COMPOUND AND DHEA OR DHEA-S | Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. (IT) | 2000-02-09 | — | — | EP | claimed |
| WO-1998046233-A1 | OSTEOBLAST-PROMOTING PHARMACEUTICAL COMPOSITION COMPRISING A CARNITINE COMPOUND AND DHEA OR DHEA-S | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 1998-10-22 | — | — | WO | claimed |