Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 6/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | NAMPT | P43490 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13633779 | 0.94 | P2RY12 (0.36) | CNR1P2RY12 | |
| SCHEMBL12161541 | 0.87 | EPHX2 (0.43) | SMN1; SMN2CNR1EPHX2LMNAKMT2A | |
| SCHEMBL13633815 | 0.87 | P2RY12 (0.37) | P2RY12 | |
| SCHEMBL9922972 | 0.81 | EPHX2 (0.42) | SMN1; SMN2CNR1EPHX2KMT2A | |
| SCHEMBL13638572 | 0.81 | P2RY12 (0.37) | P2RY12 | |
| SCHEMBL9922601 | 0.81 | EPHX2 (0.41) | CNR1P2RY12EPHX2EGFR | |
| SCHEMBL9922261 | 0.78 | EPHX2 (0.43) | SMN1; SMN2CNR1P2RY12EPHX2MAPT | |
| SCHEMBL14228353 | 0.78 | P2RY12 (0.42) | SMN1; SMN2P2RY12MAPTLMNAHTT | |
| SCHEMBL12161536 | 0.78 | P2RY12 (0.43) | SMN1; SMN2P2RY12MAPTLMNAHTT | |
| SCHEMBL13638573 | 0.78 | P2RY12 (0.43) | SMN1; SMN2P2RY12MAPTLMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622474-B2 | Asulfonyl(urea, thiourea, guanidine, cyanoguanidine) compounds; cardiovascular disorders; thrombosis | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-24 | — | — | US | disclosed |
| US-7622474-B2 | Asulfonyl(urea, thiourea, guanidine, cyanoguanidine) compounds; cardiovascular disorders; thrombosis | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-24 | — | — | US | disclosed |