Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | FLT1 | P17948 | 1/20 | 0.40 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13270545 | 0.89 | SIRT6 (0.50) | SIRT6TDP1NPSR1ALDH1A1HTT | |
| SCHEMBL8301315 | 0.86 | SIRT6 (0.53) | SIRT6TDP1ALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL13270311 | 0.84 | ALDH1A1 (0.47) | SIRT6TDP1NPSR1ALDH1A1HTT | |
| SCHEMBL13162823 | 0.84 | SIRT6 (0.51) | SIRT6TDP1ALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL15888531 | 0.83 | ALDH1A1 (0.47) | SIRT6TDP1ALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL12201377 | 0.83 | SIRT6 (0.54) | SIRT6TDP1ALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL297962 | 0.81 | SIRT6 (0.49) | SIRT6TDP1ALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL30361221 | 0.80 | SIRT6 (0.52) | SIRT6TDP1ALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL147719 | 0.80 | SIRT6 (0.52) | SIRT6TDP1ALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL6693120 | 0.79 | SIRT6 (0.53) | SIRT6TDP1ALDH1A1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8304547-B2 | Azolecarboxamide compound or salt thereof | ASTELLAS PHARMA INC. (JP) | 2012-11-06 | — | — | US | disclosed |