Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 2/20 | 0.46 |
| ▸ | PNMT | P11086 | 2/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 4/20 | 0.42 |
| ▸ | HTR2C | P28335 | 4/20 | 0.42 |
| ▸ | HTR2B | P41595 | 2/20 | 0.42 |
| ▸ | TRPM5 | Q9NZQ8 | 8/20 | 0.40 |
| ▸ | TRPM4 | Q8TD43 | 6/20 | 0.40 |
| ▸ | CMA1 | P23946 | 1/20 | 0.40 |
| ▸ | AHR | P35869 | 1/20 | 0.40 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.38 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.37 |
| ▸ | HTR3B | O95264 | 1/20 | 0.37 |
| ▸ | HTR3A | P46098 | 1/20 | 0.37 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.37 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15896885 | 0.80 | PNMT (0.47) | ADRA2APNMTADRA2BADRA2CBRD4 | |
| SCHEMBL550480 | 0.79 | PNMT (0.46) | ADRA2APNMTADRA2BADRA2CBRD4 | |
| SCHEMBL27528311 | 0.77 | ITGB3 (0.47) | TRPM5TRPM4CMA1AHR | |
| SCHEMBL15445210 | 0.76 | PNMT (0.44) | ADRA2APNMTADRA2BADRA2CBRD4 | |
| SCHEMBL7897325 | 0.76 | CMA1 (0.43) | ADRA2AADRA2BADRA2CBRD4CREBBP | |
| SCHEMBL549073 | 0.76 | CREBBP (0.59) | ADRA2APNMTADRA2BADRA2CBRD4 | |
| SCHEMBL22955423 | 0.76 | CREBBP (0.59) | ADRA2APNMTADRA2BADRA2CBRD4 | |
| SCHEMBL10841342 | 0.75 | AR (0.43) | ADRA2APNMTADRA2BADRA2CHTR2A | |
| SCHEMBL25696612 | 0.74 | MGAM (0.37) | ADRA2APNMTADRA2BADRA2CBRD4 | |
| SCHEMBL20804518 | 0.73 | AR (0.40) | BRD4CREBBPHTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612075-B2 | Substituted oxoazaheterocyclyl compounds | AVENTIS PHARMACEUTICALS INC. (US) | 2009-11-03 | — | — | US | disclosed |