Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.64 |
| ▸ | RAB9A | P51151 | 2/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | GLA | P06280 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | NAMPT | P43490 | 2/20 | 0.47 |
| ▸ | FASN | P49327 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13162643 | 1.00 | NPC1 (0.64) | NPC1RAB9ASMN1; SMN2GLAPOLB | |
| SCHEMBL13162693 | 0.91 | NPC1 (0.72) | NPC1RAB9ASMN1; SMN2GLAPOLB | |
| SCHEMBL29062256 | 0.89 | TAS1R3 (0.54) | NPC1RAB9ASMN1; SMN2GLAPOLB | |
| SCHEMBL13162654 | 0.88 | NPC1 (0.67) | NPC1RAB9ASMN1; SMN2GLAPOLB | |
| SCHEMBL27171970 | 0.84 | CNR2 (0.49) | NPC1RAB9ASMN1; SMN2ALDH1A1GAA | |
| SCHEMBL27204928 | 0.84 | CNR2 (0.49) | NPC1RAB9ASMN1; SMN2ALDH1A1GAA | |
| SCHEMBL457993 | 0.82 | NPC1 (0.84) | NPC1RAB9ASMN1; SMN2GLAPOLB | |
| SCHEMBL28949389 | 0.82 | CRBN (0.48) | NPC1RAB9ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL13162036 | 0.81 | NAMPT (0.50) | NPC1RAB9ASMN1; SMN2NAMPTFASN | |
| SCHEMBL13162009 | 0.81 | NAMPT (0.50) | NPC1RAB9ASMN1; SMN2NAMPTFASN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2206707-B1 | AZOLECARBOXAMIDE COMPOUND OR SALT THEREOF | ASTELLAS PHARMA INC (JP) | 2014-07-23 | — | — | EP | disclosed |
| US-8304547-B2 | Azolecarboxamide compound or salt thereof | ASTELLAS PHARMA INC. (JP) | 2012-11-06 | — | — | US | disclosed |
| US-8304547-B2 | Azolecarboxamide compound or salt thereof | ASTELLAS PHARMA INC. (JP) | 2012-11-06 | — | — | US | disclosed |