Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.54 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.54 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | PTGES | O14684 | 1/20 | 0.44 |
| ▸ | FASN | P49327 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 2/20 | 0.43 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HPGDS | O60760 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20477095 | 0.92 | SMN1; SMN2 (0.57) | TAS1R3TAS1R1TAS1R2NPC1RAB9A | |
| SCHEMBL13634628 | 0.89 | NPC1 (0.64) | NPC1RAB9ASMN1; SMN2GLAFASN | |
| SCHEMBL13162643 | 0.89 | NPC1 (0.64) | NPC1RAB9ASMN1; SMN2GLAFASN | |
| SCHEMBL1987660 | 0.84 | TAS1R3 (0.64) | TAS1R3TAS1R1TAS1R2NPC1RAB9A | |
| SCHEMBL13162693 | 0.80 | NPC1 (0.72) | NPC1RAB9ASMN1; SMN2GLAPOLB | |
| SCHEMBL27204928 | 0.79 | CNR2 (0.49) | NPC1RAB9ASMN1; SMN2NAMPTHPGDS | |
| SCHEMBL27171970 | 0.79 | CNR2 (0.49) | NPC1RAB9ASMN1; SMN2NAMPTHPGDS | |
| SCHEMBL14688259 | 0.78 | TAS1R3 (0.62) | TAS1R3TAS1R1TAS1R2NPC1RAB9A | |
| SCHEMBL28503120 | 0.77 | P2RX7 (0.47) | TAS1R3TAS1R1TAS1R2NPC1RAB9A | |
| SCHEMBL28949389 | 0.77 | CRBN (0.48) | NPC1RAB9ASMN1; SMN2NAMPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117069728-A | PI4KIII beta inhibitors | 葛兰素史克知识产权开发有限公司 | 2023-11-17 | — | — | CN | claimed |
| CN-111868063-B | PI4KIII beta inhibitors | 葛兰素史克知识产权开发有限公司 | 2023-08-01 | — | — | CN | claimed |
| CN-117069728-A | PI4KIII beta inhibitors | 葛兰素史克知识产权开发有限公司 | 2023-11-17 | — | — | CN | disclosed |