SCHEMBL13634727

SCHEMBL13634727

COc1ccc(C2COCCN2C)cc1

nearest known ligand 0.59

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.44
MAPK1 P28482 1/20 0.43
KDM4E B2RXH2 1/20 0.42
DRD2 P14416 1/20 0.41
ALDH1A1 P00352 2/20 0.41
POLB P06746 2/20 0.40
MMP1 P03956 1/20 0.40
MMP3 P08254 1/20 0.40
MMP13 P45452 1/20 0.40
CHRNA7 P36544 1/20 0.39
FKBP1A P62942 1/20 0.39
AKR1C3 P42330 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27367885 0.80 ATR (0.40) KDM4ECHRNA7
SCHEMBL2606078 0.80 ATR (0.40) KDM4ECHRNA7
SCHEMBL30433564 0.80 MDM2 (0.39) ALDH1A1CHRNA7
SCHEMBL13634754 0.80 CCNC (0.42) SMN1; SMN2DRD2ALDH1A1CHRNA7
SCHEMBL16130585 0.80 CHRNB2 (0.55) POLBCHRNA7
SCHEMBL16130557 0.80 CHRNB2 (0.55) POLBCHRNA7
SCHEMBL2606087 0.80 CHRNB2 (0.55) POLBCHRNA7
Bromide SCHEMBL5224743 0.78 CHRNB2 (0.53) POLBCHRNA7
SCHEMBL20632145 0.77 GAK (0.39) DRD2ALDH1A1
SCHEMBL15888678 0.75 MEN1 (0.36) ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025201504-A1 KAT6 INHIBITORS BEIGENE (SUZHOU) CO., LTD. (CN) 2025-10-02 WO disclosed
US-20250304535-A1 KAT6 Inhibitors BEIGENE SWITZERLAND GMBH (CH) 2025-10-02 US disclosed
US-20250122152-A1 KAT6 Inhibitors BEIGENE SWITZERLAND GMBH (CH) 2025-04-17 US disclosed
WO-2025068943-A1 KAT6 INHIBITORS BEIGENE SWITZERLAND GMBH (CH) 2025-04-03 WO disclosed
US-8304547-B2 Azolecarboxamide compound or salt thereof ASTELLAS PHARMA INC. (JP) 2012-11-06 US disclosed
US-8304547-B2 Azolecarboxamide compound or salt thereof ASTELLAS PHARMA INC. (JP) 2012-11-06 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250304535-A1 KAT6 Inhibitors KAT6A, KAT6B, KAT2A SMN1; SMN2 1106/4885MAPK1 1758/4885KDM4E 349/4885
US-20250122152-A1 KAT6 Inhibitors KAT6A, KAT6B, KAT7 SMN1; SMN2 1499/4885MAPK1 1526/4885KDM4E 948/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.