Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | TSPO | P30536 | 1/20 | 0.48 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.48 |
| ▸ | EDNRB | P24530 | 1/20 | 0.46 |
| ▸ | EDNRA | P25101 | 1/20 | 0.46 |
| ▸ | CMA1 | P23946 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | CD74 | P04233 | 1/20 | 0.44 |
| ▸ | MIF | P14174 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30616062 | 0.86 | KMT2A (0.62) | KMT2APOLBKDM4EDNM1ALDH1A1 | |
| SCHEMBL29093447 | 0.86 | KMT2A (0.62) | KMT2APOLBKDM4EDNM1ALDH1A1 | |
| SCHEMBL21365454 | 0.81 | P2RX4 (0.72) | KMT2APOLBKDM4EALDH1A1L3MBTL1 | |
| SCHEMBL28900325 | 0.80 | CYP19A1 (0.58) | KMT2APTGER4KDM4EALDH1A1P2RX4 | |
| SCHEMBL13062129 | 0.80 | HCAR3 (0.55) | KMT2APOLBPTGER4ALDH1A1TSPO | |
| SCHEMBL13011250 | 0.79 | MAPT (0.53) | KMT2APOLBPTGER4KDM4EDNM1 | |
| SCHEMBL243322 | 0.77 | MIF (0.73) | KMT2APOLBALDH1A1CD74MIF | |
| SCHEMBL19896378 | 0.76 | PIK3R1 (0.53) | KMT2APOLBKDM4EALDH1A1L3MBTL1 | |
| SCHEMBL689666 | 0.75 | CYP19A1 (0.64) | KMT2APOLBPTGER4KDM4EALDH1A1 | |
| SCHEMBL13011675 | 0.75 | PLA2G2A (0.48) | KMT2APOLBTSPOEDNRBEDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2119704-A1 | ACYLGUANIDINE DERIVATIVE | Astellas Pharma Inc. (JP) | 2009-11-18 | — | — | EP | disclosed |