Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 13/20 | 0.78 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.41 |
| ▸ | PDE1A | P54750 | 1/20 | 0.40 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4392919 | 0.93 | MAPK14 (0.89) | MAPK14POLBTHRBMAOBPDE1C | |
| SCHEMBL13635875 | 0.89 | MAPK14 (0.66) | MAPK14 | |
| SCHEMBL4467417 | 0.89 | MAPK14 (0.89) | MAPK14POLBTHRBPDE1CKDM4E | |
| SCHEMBL4379163 | 0.88 | MAPK14 (1.00) | MAPK14SMN1; SMN2 | |
| SCHEMBL4382379 | 0.87 | MAPK14 (0.82) | MAPK14POLBTHRBMAOBPDE1C | |
| SCHEMBL4471003 | 0.87 | MAPK14 (0.78) | MAPK14POLBMAOB | |
| SCHEMBL13635874 | 0.87 | MAPK14 (0.63) | MAPK14POLBALDH1A1SMN1; SMN2 | |
| SCHEMBL4386801 | 0.87 | MAPK14 (0.78) | MAPK14POLBTHRBALDH1A1SMN1; SMN2 | |
| SCHEMBL4489729 | 0.85 | MAPK14 (0.75) | MAPK14MAOBKDM4E | |
| SCHEMBL13635370 | 0.83 | MAPK14 (0.74) | MAPK14POLBTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490064-B1 | SUBSTITUTED PYRIDINONES AS MODULATORS OF P38 MAP KINASE | PHARMACIA CORP (US) | 2009-11-18 | — | — | EP | disclosed |