Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 11/20 | 0.63 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4485643 | 0.88 | MAPK14 (0.73) | MAPK14MAPTTP53EGLN1LMNA | |
| SCHEMBL13635875 | 0.87 | MAPK14 (0.66) | MAPK14 | |
| SCHEMBL4386801 | 0.87 | MAPK14 (0.78) | MAPK14MAPTTP53EGLN1LMNA | |
| SCHEMBL13635186 | 0.87 | MAPK14 (0.78) | MAPK14POLBALDH1A1SMN1; SMN2 | |
| SCHEMBL4478817 | 0.85 | MAPK14 (0.82) | MAPK14MAPTTP53EGLN1LMNA | |
| SCHEMBL4392919 | 0.79 | MAPK14 (0.89) | MAPK14MAPTPOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL4470415 | 0.78 | MAPK14 (1.00) | MAPK14ALDH1A1SMN1; SMN2HTT | |
| SCHEMBL4469536 | 0.78 | MAPK14 (0.87) | MAPK14EGLN1LMNAPOLBALDH1A1 | |
| SCHEMBL4468370 | 0.78 | MAPK14 (0.87) | MAPK14EGLN1LMNAPOLBALDH1A1 | |
| SCHEMBL4477450 | 0.77 | MAPK14 (0.88) | MAPK14MAPTTP53EGLN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490064-B1 | SUBSTITUTED PYRIDINONES AS MODULATORS OF P38 MAP KINASE | PHARMACIA CORP (US) | 2009-11-18 | — | — | EP | disclosed |