Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERCC1 | P07992 | 1/20 | 0.46 |
| ▸ | FEN1 | P39748 | 1/20 | 0.46 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27637025 | 0.88 | CA12 (0.46) | ERCC1FEN1ERCC4CA12CA1 | |
| SCHEMBL27657927 | 0.86 | ERCC1 (0.41) | ERCC1FEN1ERCC4CA12CA1 | |
| SCHEMBL4425568 | 0.83 | ERCC1 (0.49) | ERCC1FEN1ERCC4TP53MAPT | |
| SCHEMBL682017 | 0.83 | KDM4E (0.46) | ERCC1FEN1ERCC4CA12CA1 | |
| SCHEMBL681267 | 0.82 | P2RY12 (0.47) | ERCC1FEN1ERCC4CA12CA1 | |
| SCHEMBL8737599 | 0.80 | P2RY12 (0.46) | ERCC1FEN1ERCC4CA12CA1 | |
| SCHEMBL13362572 | 0.79 | FEN1 (0.45) | ERCC1FEN1ERCC4CA12CA1 | |
| SCHEMBL1162470 | 0.75 | ALDH1A1 (0.49) | ERCC1FEN1ERCC4CA12CA1 | |
| SCHEMBL1180474 | 0.74 | JAK2 (0.50) | ERCC1FEN1ERCC4CA12CA1 | |
| SCHEMBL4425764 | 0.73 | TP53 (0.45) | TP53MAPTALDH1A1KMT2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1668002-B1 | 2,4-DIOXO-3-QUINAZOLINYLARYL SULFONYLUREAS | PORTOLA PHARM INC (US) | 2009-11-11 | — | — | EP | disclosed |