Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERCC1 | P07992 | 2/20 | 0.49 |
| ▸ | FEN1 | P39748 | 2/20 | 0.49 |
| ▸ | ERCC4 | Q92889 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | DNASE1 | P24855 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13635263 | 0.83 | ERCC1 (0.46) | ERCC1FEN1ERCC4TP53MAPT | |
| SCHEMBL1162470 | 0.81 | ALDH1A1 (0.49) | ERCC1FEN1ERCC4TP53MAPT | |
| SCHEMBL6982187 | 0.80 | GAA (0.59) | ERCC1FEN1ERCC4TP53MAPT | |
| Isophthalic Acid SCHEMBL9859697 | 0.77 | KDM4E (0.52) | TP53MAPTRXFP1LMNAKMT2A | |
| SCHEMBL681255 | 0.75 | ALDH1A1 (0.56) | TP53MAPTRXFP1LMNAKMT2A | |
| SCHEMBL1548586 | 0.73 | TP53 (0.62) | ERCC1FEN1ERCC4TP53MAPT | |
| SCHEMBL27637025 | 0.73 | CA12 (0.46) | ERCC1FEN1ERCC4TP53MAPT | |
| SCHEMBL328468 | 0.72 | KDM4E (0.49) | FEN1TP53LMNAKMT2AALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL1548567 | 0.72 | GAA (0.53) | ERCC1FEN1ERCC4TP53MAPT | |
| Hydrochloric Acid SCHEMBL251791 | 0.71 | KDM4E (0.48) | TP53LMNAKMT2AALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1668002-B1 | 2,4-DIOXO-3-QUINAZOLINYLARYL SULFONYLUREAS | PORTOLA PHARM INC (US) | 2009-11-11 | — | — | EP | disclosed |
| EP-1668002-A4 | 2,4-DIOXO-3-QUINAZOLINYLARYL SULFONYLUREAS | PORTOLA PHARM INC (US) | 2006-12-20 | — | — | EP | disclosed |
| US-7109332-B2 | 2,4-dioxo-3-quinazolinylaryl sulfonylureas | PORTOLA PHARMACEUTICALS, INC. (US) | 2006-09-19 | — | — | US | disclosed |
| EP-1668002-A2 | 2,4-DIOXO-3-QUINAZOLINYLARYL SULFONYLUREAS | Portola Pharmaceuticals, Inc. (US) | 2006-06-14 | — | — | EP | disclosed |
| US-20050107357-A1 | 2,4-dioxo-3-quinazolinylaryl sulfonylureas | PORTOLA PHARMACEUTICALS, INC. (US) | 2005-05-19 | — | — | US | disclosed |
| WO-2005032488-A2 | 2,4-DIOXO-3-QUINAZOLINYLARYL SULFONYLUREAS | PORTOLA PHARMACEUTICALS, INC. (US) | 2005-04-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050107357-A1 | 2,4-dioxo-3-quinazolinylaryl sulfonylureas | PFKP, DPP3, P2RY13 | ERCC1 4555/4885FEN1 4415/4885ERCC4 4379/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.