Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | MYC | P01106 | 2/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 2/20 | 0.33 |
| ▸ | BTK | Q06187 | 2/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4376841 | 0.86 | ALDH1A1 (0.60) | POLBALDH1A1RAB9AL3MBTL1TDP1 | |
| SCHEMBL27765709 | 0.71 | NOTUM (0.51) | POLBALDH1A1RAB9AL3MBTL1NOTUM | |
| SCHEMBL16332319 | 0.69 | NOTUM (0.54) | POLBALDH1A1RAB9ATDP1NOTUM | |
| SCHEMBL4381208 | 0.67 | ANPEP (0.45) | POLBALDH1A1L3MBTL1TDP1MAPK14 | |
| SCHEMBL4377764 | 0.66 | ALDH1A1 (0.52) | POLBALDH1A1L3MBTL1TDP1MYC | |
| SCHEMBL4379826 | 0.66 | ALDH1A1 (0.60) | POLBALDH1A1RAB9AL3MBTL1TDP1 | |
| SCHEMBL2706645 | 0.66 | ALDH1A1 (0.60) | POLBALDH1A1L3MBTL1TDP1NOTUM | |
| SCHEMBL4387429 | 0.66 | ALDH1A1 (0.47) | ALDH1A1RAB9AL3MBTL1TDP1MYC | |
| SCHEMBL24759727 | 0.65 | POLB (0.37) | POLBALDH1A1LMNA | |
| SCHEMBL4389760 | 0.65 | APLNR (0.54) | POLBALDH1A1L3MBTL1MAPK14TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490064-B1 | SUBSTITUTED PYRIDINONES AS MODULATORS OF P38 MAP KINASE | PHARMACIA CORP (US) | 2009-11-18 | — | — | EP | disclosed |