Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 6/20 | 0.52 |
| ▸ | BRAF | P15056 | 4/20 | 0.47 |
| ▸ | MET | P08581 | 8/20 | 0.43 |
| ▸ | KDR | P35968 | 6/20 | 0.40 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.40 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | LYN | P07948 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | HCK | P08631 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | BCR | P11274 | 1/20 | 0.40 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.40 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | ABL2 | P42684 | 1/20 | 0.40 |
| ▸ | FRK | P42685 | 1/20 | 0.40 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14290052 | 0.84 | MET (0.44) | MAPK14METKDRRIPK2ABL1 | |
| SCHEMBL15015146 | 0.81 | MET (0.62) | METKDRRETFLT3 | |
| SCHEMBL3561767 | 0.81 | MAPK14 (0.61) | MAPK14BRAFMETKDRABL1 | |
| SCHEMBL13635722 | 0.81 | MET (0.53) | MAPK14BRAFMETKDREPHB6 | |
| SCHEMBL139145 | 0.81 | MET (0.59) | MAPK14METKDREPHB6RIPK2 | |
| SCHEMBL14290084 | 0.81 | MAPK14 (0.52) | MAPK14BRAFMETKDREPHB6 | |
| Hydrochloric Acid SCHEMBL3560789 | 0.80 | MET (0.58) | MAPK14METKDREPHB6RIPK2 | |
| SCHEMBL13635345 | 0.78 | MAPK14 (0.34) | MAPK14BRAFMETKDREPHB6 | |
| SCHEMBL2854954 | 0.78 | MAPK14 (0.60) | MAPK14BRAFMETKDRRIPK2 | |
| SCHEMBL13635260 | 0.77 | MET (0.47) | MAPK14BRAFMETKDREPHB6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1889836-B1 | NOVEL PYRIDINE DERIVATIVE AND PYRIMIDINE DERIVATIVE (3) | EISAI R&D MAN CO LTD (JP) | 2013-06-12 | — | — | EP | disclosed |
| EP-2119706-A1 | PYRIDINE OR PYRIMIDINE DERIVATIVE HAVING EXCELLENT CELL GROWTH INHIBITION EFFECT AND EXCELLENT ANTI-TUMOR EFFECT ON CELL STRAIN HAVING AMPLIFICATION OF HGFR GENE | Eisai R&D Management Co., Ltd. (JP) | 2009-11-18 | — | — | EP | disclosed |
| EP-1889836-A1 | NOVEL PYRIDINE DERIVATIVE AND PYRIMIDINE DERIVATIVE (3) | Eisai R&D Management Co., Ltd. (JP) | 2008-02-20 | — | — | EP | disclosed |