Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 5/20 | 0.34 |
| ▸ | KDR | P35968 | 13/20 | 0.32 |
| ▸ | MET | P08581 | 3/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.32 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.32 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | LCK | P06239 | 1/20 | 0.32 |
| ▸ | LYN | P07948 | 1/20 | 0.32 |
| ▸ | RET | P07949 | 1/20 | 0.32 |
| ▸ | HCK | P08631 | 1/20 | 0.32 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.32 |
| ▸ | BCR | P11274 | 1/20 | 0.32 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.32 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.32 |
| ▸ | FLT3 | P36888 | 1/20 | 0.32 |
| ▸ | ABL2 | P42684 | 1/20 | 0.32 |
| ▸ | FRK | P42685 | 1/20 | 0.32 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.32 |
| ▸ | EPHB3 | P54753 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14865203 | 0.86 | KDR (0.37) | MAPK14KDRMETNTRK1EPHB6 | |
| SCHEMBL14290055 | 0.83 | FLT3 (0.32) | METFLT3 | |
| SCHEMBL15015145 | 0.82 | MET (0.49) | MAPK14KDRMETNTRK1EPHB6 | |
| SCHEMBL13635346 | 0.78 | MAPK14 (0.52) | MAPK14KDRMETNTRK1EPHB6 | |
| SCHEMBL13635344 | 0.72 | ALDH1A1 (0.34) | — | |
| SCHEMBL14289923 | 0.65 | RAB9A (0.53) | — | |
| SCHEMBL13635347 | 0.65 | SLC6A2 (0.40) | — | |
| SCHEMBL13635721 | 0.64 | ALDH1A1 (0.45) | — | |
| SCHEMBL14290052 | 0.62 | MET (0.44) | MAPK14KDRMETNTRK1RIPK2 | |
| SCHEMBL3561475 | 0.61 | RAF1 (0.47) | MAPK14KDRMETNTRK1EPHB6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2119706-A1 | PYRIDINE OR PYRIMIDINE DERIVATIVE HAVING EXCELLENT CELL GROWTH INHIBITION EFFECT AND EXCELLENT ANTI-TUMOR EFFECT ON CELL STRAIN HAVING AMPLIFICATION OF HGFR GENE | Eisai R&D Management Co., Ltd. (JP) | 2009-11-18 | — | — | EP | disclosed |