Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 7/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.40 |
| ▸ | HTR1A | P08908 | 3/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7938427 | 0.69 | MAPT (0.46) | SLC6A2SLC6A4SLC6A3HTR1AMAP4K4 | |
| SCHEMBL6293197 | 0.67 | ALDH1A1 (0.50) | SLC6A2SLC6A4SLC6A3HTR1AMAP4K4 | |
| SCHEMBL6293224 | 0.67 | ALDH1A1 (0.50) | SLC6A2SLC6A4SLC6A3HTR1AMAP4K4 | |
| SCHEMBL6289878 | 0.67 | ALDH1A1 (0.50) | SLC6A2SLC6A4SLC6A3HTR1AMAP4K4 | |
| SCHEMBL6290410 | 0.67 | ALDH1A1 (0.50) | SLC6A2SLC6A4SLC6A3HTR1AMAP4K4 | |
| SCHEMBL6289927 | 0.67 | ALDH1A1 (0.50) | SLC6A2SLC6A4SLC6A3HTR1AMAP4K4 | |
| SCHEMBL5492733 | 0.67 | MAOB (0.67) | SLC6A2SLC6A4SLC6A3MAP4K4POLB | |
| SCHEMBL1339341 | 0.66 | GAA (0.64) | SLC6A2SLC6A4SLC6A3HTR1AMAP4K4 | |
| SCHEMBL6289347 | 0.65 | ALDH1A1 (0.54) | SLC6A2SLC6A4SLC6A3HTR1AKCNH2 | |
| SCHEMBL6290496 | 0.65 | ALDH1A1 (0.54) | SLC6A2SLC6A4SLC6A3HTR1AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2119706-A1 | PYRIDINE OR PYRIMIDINE DERIVATIVE HAVING EXCELLENT CELL GROWTH INHIBITION EFFECT AND EXCELLENT ANTI-TUMOR EFFECT ON CELL STRAIN HAVING AMPLIFICATION OF HGFR GENE | Eisai R&D Management Co., Ltd. (JP) | 2009-11-18 | — | — | EP | disclosed |