Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | DRD3 | P35462 | 2/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
| ▸ | CDK4 | P11802 | 1/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13198250 | 0.92 | HDAC6 (0.50) | LMNAHDAC3HDAC1HDAC2HDAC4 | |
| SCHEMBL4331810 | 0.89 | KDR (0.42) | KDM4EALDH1A1LMNAHDAC3HDAC1 | |
| SCHEMBL4348178 | 0.88 | LMNA (0.45) | MAPTLMNAHDAC3HDAC1HDAC2 | |
| SCHEMBL2864362 | 0.84 | GSK3B (0.44) | DRD2KDRCDK4CCNA2CCND1 | |
| SCHEMBL4335936 | 0.84 | BRD4 (0.47) | ALDH1A1MAPTKDRCDK4CCNA2 | |
| SCHEMBL4335955 | 0.84 | RCE1 (0.54) | KDM4EALDH1A1LMNATSHRNPC1 | |
| SCHEMBL2864594 | 0.83 | KDR (0.47) | KDRCDK4CCNA2CCND1CDK2 | |
| SCHEMBL4334496 | 0.83 | MEN1 (0.41) | DRD2DRD3KDRCDK4CCNA2 | |
| SCHEMBL4341067 | 0.83 | RAB9A (0.46) | KDM4EALDH1A1MAPTLMNATSHR | |
| SCHEMBL2856935 | 0.83 | SMN1; SMN2 (0.54) | KDM4EALDH1A1MAPTHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1380576-B1 | 1H-INDAZOLE COMPOUNDS INHIBITING JNK | EISAI R&D MAN CO LTD (JP) | 2009-11-25 | — | — | EP | disclosed |