Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 1/20 | 0.48 |
| ▸ | TEK | Q02763 | 1/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 13/20 | 0.46 |
| ▸ | NT5E | P21589 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16474759 | 0.86 | ROCK2 (0.53) | ROCK2 | |
| SCHEMBL16474758 | 0.85 | ROCK2 (0.48) | ROCK2 | |
| SCHEMBL10059575 | 0.84 | AKT2 (0.51) | ROCK2KDM4EALDH1A1CYP1A2HPGD | |
| SCHEMBL18077736 | 0.81 | ROCK2 (0.43) | KDRTEKROCK2 | |
| SCHEMBL16474763 | 0.81 | HTT (0.51) | TEKROCK2KDM4EALDH1A1MAPT | |
| SCHEMBL10059948 | 0.81 | ALDH1A1 (0.53) | KDM4EALDH1A1MAPTSMN1; SMN2MAPK14 | |
| SCHEMBL13575375 | 0.80 | ROCK2 (0.51) | ROCK2KMT2A | |
| SCHEMBL10059838 | 0.80 | ROCK2 (0.54) | ROCK2KDM4EMAPT | |
| SCHEMBL13635444 | 0.77 | ALDH1A1 (0.45) | KDM4EALDH1A1MAPTSMN1; SMN2MAPK14 | |
| SCHEMBL10059586 | 0.77 | CHEK1 (0.42) | ROCK2CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8304413-B2 | Compounds and methods for treating inflammatory and fibrotic disorders | INTERMUNE, INC. (US) | 2012-11-06 | — | — | US | disclosed |