Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | RIPK3 | Q9Y572 | 4/20 | 0.34 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 2/20 | 0.33 |
| ▸ | AGXT | P21549 | 2/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 2/20 | 0.33 |
| ▸ | HTR2C | P28335 | 2/20 | 0.33 |
| ▸ | GSK3A | P49840 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | SNCA | P37840 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8236340 | 0.84 | MAOA (0.41) | MAOAMAOBTRPV4DPP4RORC | |
| SCHEMBL7661361 | 0.80 | MAOA (0.38) | MAOAMAOBRIPK3TRPV4DPP4 | |
| SCHEMBL534825 | 0.80 | MAOA (0.38) | MAOAMAOBRIPK3TRPV4DPP4 | |
| SCHEMBL19437243 | 0.80 | MAOA (0.38) | MAOAMAOBRIPK3TRPV4DPP4 | |
| SCHEMBL8415471 | 0.80 | AR (0.39) | MAOAMAOBRIPK3DPP4RORC | |
| SCHEMBL24302232 | 0.80 | MAOA (0.38) | MAOAMAOBRIPK3TRPV4DPP4 | |
| SCHEMBL12215809 | 0.80 | MPO (0.41) | MAOAMAOBTRPV4DPP4IDO1 | |
| SCHEMBL31533623 | 0.80 | MAOA (0.38) | MAOAMAOBRIPK3TRPV4DPP4 | |
| SCHEMBL18245710 | 0.77 | MAOA (0.36) | MAOAMAOBRIPK3TRPV4DPP4 | |
| SCHEMBL18246279 | 0.77 | FFAR1 (0.37) | MAOAMAOBRIPK3TRPV4DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490064-B1 | SUBSTITUTED PYRIDINONES AS MODULATORS OF P38 MAP KINASE | PHARMACIA CORP (US) | 2009-11-18 | — | — | EP | disclosed |
| EP-1506967-B1 | Dipeptidyl peptidase inhibitors | TAKEDA PHARMACEUTICAL (JP) | 2007-11-21 | — | — | EP | disclosed |