Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 5/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.38 |
| ▸ | GNRHR | P30968 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.35 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.35 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4377722 | 0.88 | GNRHR (0.38) | MAPK14RAB9ASMN1; SMN2BRD4BRD9 | |
| SCHEMBL4375953 | 0.70 | MAPK14 (0.37) | MAPK14GNRHRPDE7APDE4APDE4B | |
| SCHEMBL4469946 | 0.70 | MAPK14 (0.41) | MAPK14RAB9ASMN1; SMN2GNRHRNPC1 | |
| SCHEMBL4377030 | 0.70 | MAPK14 (0.46) | MAPK14RAB9ASMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL10546027 | 0.68 | KMT2A (0.50) | MAPTMAPK1LMNAHTTCA12 | |
| SCHEMBL4378496 | 0.67 | MAPK14 (0.75) | MAPK14 | |
| SCHEMBL3525531 | 0.66 | MAPK14 (0.47) | MAPK14RAB9ASMN1; SMN2ALDH1A1PDE7A | |
| SCHEMBL21667355 | 0.64 | MEN1 (0.47) | MAPK14SMN1; SMN2ALDH1A1MAPTHPGD | |
| SCHEMBL13887501 | 0.64 | MAPKAPK2 (0.53) | SMN1; SMN2BRD4BRD9ALDH1A1MAPT | |
| SCHEMBL4477435 | 0.63 | NFE2L2 (0.41) | MAPK14RAB9ASMN1; SMN2LMNAPDE7A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490064-B1 | SUBSTITUTED PYRIDINONES AS MODULATORS OF P38 MAP KINASE | PHARMACIA CORP (US) | 2009-11-18 | — | — | EP | disclosed |