Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 5/20 | 0.52 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.46 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.46 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.43 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.42 |
| ▸ | WNT1 | P04628 | 1/20 | 0.42 |
| ▸ | GSK3A | P49840 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2866826 | 0.90 | DYRK1A (0.52) | DYRK1AMAP4K4LRRK2MAP3K5KDR | |
| SCHEMBL2861298 | 0.87 | DYRK1A (0.49) | DYRK1AMAP4K4LRRK2MAP3K5KDR | |
| SCHEMBL2861793 | 0.80 | DYRK1A (0.53) | DYRK1AMAP4K4LRRK2MAP3K5KDR | |
| SCHEMBL2866807 | 0.79 | DYRK1A (0.52) | DYRK1AMAP4K4LRRK2MAP3K5KDR | |
| SCHEMBL2862730 | 0.79 | DYRK1A (0.59) | DYRK1AMAP3K5 | |
| SCHEMBL2868590 | 0.78 | DYRK1A (0.50) | DYRK1AMAP4K4MAP2K4GSK3AGSK3B | |
| SCHEMBL4149434 | 0.77 | DYRK1A (0.52) | DYRK1AMAP4K4MAP3K5MAP2K4WNT1 | |
| SCHEMBL2861587 | 0.76 | KDR (0.49) | DYRK1ALRRK2KDRWNT1GSK3B | |
| SCHEMBL2872480 | 0.76 | DYRK1A (0.56) | DYRK1ALRRK2MAP3K5 | |
| SCHEMBL2872484 | 0.76 | DYRK1A (0.56) | DYRK1ALRRK2MAP3K5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1380576-B1 | 1H-INDAZOLE COMPOUNDS INHIBITING JNK | EISAI R&D MAN CO LTD (JP) | 2009-11-25 | — | — | EP | disclosed |