Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CCNC | P24863 | 1/20 | 0.36 |
| ▸ | CDK8 | P49336 | 1/20 | 0.36 |
| ▸ | CLK2 | P49760 | 7/20 | 0.36 |
| ▸ | CLK3 | P49761 | 7/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 7/20 | 0.36 |
| ▸ | GSK3A | P49840 | 2/20 | 0.35 |
| ▸ | GSK3B | P49841 | 2/20 | 0.35 |
| ▸ | WNT1 | P04628 | 3/20 | 0.35 |
| ▸ | TTK | P33981 | 1/20 | 0.35 |
| ▸ | FUCA1 | P04066 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.35 |
| ▸ | WNT3A | P56704 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2868379 | 0.78 | TTK (0.47) | CCNCCDK8GSK3AGSK3BTTK | |
| SCHEMBL4341417 | 0.77 | GSK3A (0.55) | CLK2CLK3DYRK1AGSK3AGSK3B | |
| SCHEMBL2864566 | 0.76 | TTK (0.55) | ALDH1A1TTKL3MBTL1 | |
| SCHEMBL2868892 | 0.76 | KMT2A (0.48) | ALDH1A1CCNCCDK8TTKWNT3A | |
| SCHEMBL4343149 | 0.72 | PARP1 (0.45) | GSK3AGSK3BWNT1 | |
| SCHEMBL4332106 | 0.72 | MAPK10 (0.47) | DYRK1AGSK3AGSK3BWNT1 | |
| SCHEMBL4332595 | 0.72 | PARP1 (0.45) | GSK3AGSK3BWNT1 | |
| SCHEMBL4338783 | 0.72 | KDM4E (0.51) | ALDH1A1 | |
| SCHEMBL2865134 | 0.69 | MAP2K4 (0.51) | — | |
| SCHEMBL2863255 | 0.69 | TTK (0.47) | GSK3AGSK3BTTKNTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1380576-B1 | 1H-INDAZOLE COMPOUNDS INHIBITING JNK | EISAI R&D MAN CO LTD (JP) | 2009-11-25 | — | — | EP | disclosed |