Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA5 | P31644 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 7/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.34 |
| ▸ | GSK3A | P49840 | 1/20 | 0.34 |
| ▸ | PTAFR | P25105 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.33 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13635757 | 0.88 | ITK (0.34) | GSK3BKCNH2 | |
| SCHEMBL2866665 | 0.84 | GABRA5 (0.48) | GABRA5GSK3BCYP1A2GAACYP2C9 | |
| SCHEMBL4331604 | 0.80 | HPGD (0.61) | GSK3BCYP1A2GAACYP2C9HPGD | |
| SCHEMBL4332657 | 0.80 | HPGD (0.61) | GSK3BCYP1A2GAACYP2C9HPGD | |
| SCHEMBL2865663 | 0.77 | DYRK1A (0.48) | GABRA5GSK3BMAP2K4DYRK1AGSK3A | |
| SCHEMBL4345594 | 0.76 | HPGD (0.42) | GABRA5HPGDTP53 | |
| SCHEMBL4327002 | 0.76 | HPGD (0.58) | GAAHPGD | |
| SCHEMBL4334573 | 0.76 | TTK (0.55) | GAAHPGD | |
| SCHEMBL4334999 | 0.76 | TP53 (0.41) | CYP1A2HPGDMAP2K4PTAFRTP53 | |
| SCHEMBL4334327 | 0.75 | PARP1 (0.43) | HPGDKLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1380576-B1 | 1H-INDAZOLE COMPOUNDS INHIBITING JNK | EISAI R&D MAN CO LTD (JP) | 2009-11-25 | — | — | EP | disclosed |