Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 5/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.33 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.33 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.33 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.33 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.33 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13635754 | 0.88 | GABRA5 (0.37) | GSK3BKCNH2 | |
| SCHEMBL2862711 | 0.85 | HDAC3 (0.47) | ITKGSK3BKCNH2HDAC3HDAC4 | |
| SCHEMBL4345592 | 0.81 | MEN1 (0.51) | GSK3BKCNH2MEN1KMT2A | |
| SCHEMBL4333976 | 0.81 | MEN1 (0.51) | GSK3BKCNH2MEN1KMT2A | |
| SCHEMBL4334043 | 0.78 | PTGDR2 (0.42) | ITKMAPK1MAPTTHRBHDAC2 | |
| SCHEMBL2870995 | 0.78 | MCHR1 (0.47) | MAPK8MEN1KMT2AMCHR1 | |
| SCHEMBL4341443 | 0.77 | TP53 (0.41) | MAPK1MAPTCSNK1DMEN1KMT2A | |
| SCHEMBL4334934 | 0.77 | HPGD (0.56) | MAPK1MAPTMAPK8MEN1KMT2A | |
| SCHEMBL4331515 | 0.77 | TTK (0.49) | MAPK1MAPTKMT2A | |
| SCHEMBL4334329 | 0.77 | NPC1 (0.41) | MAPK1MAPTHDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1380576-B1 | 1H-INDAZOLE COMPOUNDS INHIBITING JNK | EISAI R&D MAN CO LTD (JP) | 2009-11-25 | — | — | EP | disclosed |