Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 3/20 | 0.45 |
| ▸ | CDK4 | P11802 | 1/20 | 0.45 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.45 |
| ▸ | CCND1 | P24385 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | CCND3 | P30281 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | ITK | Q08881 | 2/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | MAP2K4 | P45985 | 6/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.41 |
| ▸ | MAPKAPK3 | Q16644 | 4/20 | 0.41 |
| ▸ | MAPK6 | Q16659 | 4/20 | 0.41 |
| ▸ | MAPKAPK5 | Q8IW41 | 2/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.40 |
| ▸ | TTK | P33981 | 3/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | ALPL | P05186 | 1/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2861016 | 0.77 | ITK (0.68) | MAPKAPK2ITKMAPK8TTK | |
| SCHEMBL2855850 | 0.76 | MAP2K4 (0.59) | MAPKAPK2CDK4CCNA2CCND1CDK2 | |
| SCHEMBL1137614 | 0.76 | PDK2 (0.47) | MAPK1 | |
| SCHEMBL5374570 | 0.75 | MAP2K4 (0.59) | MAPKAPK2CDK4CCNA2CCND1CDK2 | |
| SCHEMBL2861069 | 0.75 | ALPL (0.54) | MAPKAPK2CDK4CCNA2CCND1CDK2 | |
| SCHEMBL13927625 | 0.73 | IDO1 (0.63) | MAPKAPK2CDK4CCNA2CCND1CDK2 | |
| SCHEMBL2867128 | 0.72 | MAPK1 (0.58) | MAPK1MAPK8TTKCSNK1D | |
| SCHEMBL2864712 | 0.72 | ITK (0.56) | MAPKAPK2ITKTTK | |
| SCHEMBL13742858 | 0.72 | CYP1A2 (0.51) | MAPKAPK2CDK4CCNA2CCND1CDK2 | |
| SCHEMBL5375303 | 0.70 | MAPT (0.73) | MAPKAPK2CDK4CCNA2CCND1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1380576-B1 | 1H-INDAZOLE COMPOUNDS INHIBITING JNK | EISAI R&D MAN CO LTD (JP) | 2009-11-25 | — | — | EP | disclosed |