Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 8/20 | 0.40 |
| ▸ | ITK | Q08881 | 5/20 | 0.37 |
| ▸ | ULK1 | O75385 | 2/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.34 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2858355 | 0.82 | PDPK1 (0.46) | PDPK1ITKULK1MAPK10 | |
| SCHEMBL13635709 | 0.79 | PDPK1 (0.38) | PDPK1ITKULK1LRRK2MAPK10 | |
| SCHEMBL2864512 | 0.63 | ITK (0.51) | PDPK1ITKULK1MAPK10 | |
| SCHEMBL13635414 | 0.62 | MAPK10 (0.44) | PDPK1ITKULK1MAPK10 | |
| SCHEMBL2871440 | 0.61 | MAPK10 (0.44) | PDPK1ITKULK1MAPK10 | |
| SCHEMBL2861387 | 0.60 | ULK1 (0.59) | PDPK1ITKULK1MAPK10 | |
| SCHEMBL2865394 | 0.59 | ALDH1A1 (0.50) | PDPK1ITKULK1MAPK10 | |
| SCHEMBL13198206 | 0.59 | PDPK1 (0.54) | PDPK1ITKULK1MAPK10 | |
| SCHEMBL15353811 | 0.59 | PDPK1 (0.61) | PDPK1ITKULK1MAPK10 | |
| SCHEMBL6426295 | 0.58 | AURKA (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1380576-B1 | 1H-INDAZOLE COMPOUNDS INHIBITING JNK | EISAI R&D MAN CO LTD (JP) | 2009-11-25 | — | — | EP | disclosed |