Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.42 |
| ▸ | HPGD | P15428 | 6/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.42 |
| ▸ | RAB9A | P51151 | 5/20 | 0.42 |
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | ITK | Q08881 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | TTK | P33981 | 1/20 | 0.38 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2870079 | 0.78 | ALDH1A1 (0.45) | ALDH1A1KDM4EHPGDSMN1; SMN2RAB9A | |
| SCHEMBL2871158 | 0.74 | KDM4E (0.51) | ALDH1A1KDM4EHPGDSMN1; SMN2ITK | |
| SCHEMBL13635742 | 0.64 | ALDH1A1 (0.39) | ALDH1A1TTK | |
| SCHEMBL19322166 | 0.63 | KDM4E (0.58) | ALDH1A1KDM4EHPGDSMN1; SMN2RAB9A | |
| SCHEMBL1494939 | 0.60 | ALDH1A1 (0.77) | ALDH1A1KDM4EHPGDSMN1; SMN2RAB9A | |
| SCHEMBL1494696 | 0.60 | KDM4E (1.00) | ALDH1A1KDM4EHPGDSMN1; SMN2RAB9A | |
| SCHEMBL2858493 | 0.60 | ITK (0.46) | ITKTTKPDPK1 | |
| SCHEMBL13401433 | 0.59 | ALDH1A1 (0.77) | ALDH1A1KDM4EHPGDSMN1; SMN2RAB9A | |
| SCHEMBL25312016 | 0.58 | ALDH1A1 (0.81) | ALDH1A1KDM4EHPGDSMN1; SMN2RAB9A | |
| SCHEMBL29484580 | 0.58 | ALDH1A1 (0.81) | ALDH1A1KDM4EHPGDSMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1380576-B1 | 1H-INDAZOLE COMPOUNDS INHIBITING JNK | EISAI R&D MAN CO LTD (JP) | 2009-11-25 | — | — | EP | disclosed |