Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 13/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.33 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4368593 | 0.93 | HSD11B1 (0.44) | HSD11B1CYP3A4LMNAKDM4EALDH1A1 | |
| SCHEMBL15151453 | 0.93 | HSD11B1 (0.44) | HSD11B1CYP3A4LMNAKDM4EALDH1A1 | |
| SCHEMBL14606975 | 0.84 | HSD11B1 (0.39) | HSD11B1CYP3A4LMNAKDM4EALDH1A1 | |
| SCHEMBL4366452 | 0.84 | HSD11B1 (0.46) | HSD11B1CYP3A4LMNAALDH1A1HPGD | |
| SCHEMBL4368782 | 0.83 | HSD11B1 (0.56) | HSD11B1CYP3A4LMNANR1I2 | |
| SCHEMBL15151354 | 0.80 | HSD11B1 (0.52) | HSD11B1CYP3A4LMNAKDM4EALDH1A1 | |
| SCHEMBL4665667 | 0.79 | HSD11B1 (0.55) | HSD11B1CYP3A4ALDH1A1 | |
| SCHEMBL4370589 | 0.79 | HSD11B1 (0.55) | HSD11B1CYP3A4ALDH1A1 | |
| SCHEMBL4367348 | 0.79 | HSD11B1 (0.55) | HSD11B1CYP3A4ALDH1A1 | |
| SCHEMBL15151353 | 0.79 | HSD11B1 (0.55) | HSD11B1CYP3A4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622492-B2 | Pyrazolones as inhibitors of 11β-hydroxysteroid dehydrogenase | HOFFMANN-LA ROCHE INC. (US) | 2009-11-24 | — | — | US | disclosed |