Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | F2R | P25116 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4378985 | 0.85 | LMNA (0.59) | LMNAHPGDKMT2AKDM4ENFE2L2 | |
| SCHEMBL14190946 | 0.85 | LMNA (0.59) | LMNAHPGDKMT2AKDM4ENFE2L2 | |
| SCHEMBL13636165 | 0.80 | HPGD (0.46) | LMNAHPGDKMT2AKDM4ENFE2L2 | |
| SCHEMBL13636199 | 0.79 | HPGD (0.45) | LMNAHPGDKMT2AKDM4ENFE2L2 | |
| SCHEMBL4379174 | 0.75 | TDP1 (0.47) | LMNAHPGDKDM4ETDP1L3MBTL1 | |
| SCHEMBL14190948 | 0.75 | TDP1 (0.47) | LMNAHPGDKDM4ETDP1L3MBTL1 | |
| SCHEMBL4378517 | 0.74 | NPC1 (0.64) | HPGDKMT2AKDM4EL3MBTL1F2R | |
| SCHEMBL13636477 | 0.74 | NPC1 (0.64) | HPGDKMT2AKDM4EL3MBTL1F2R | |
| SCHEMBL14218138 | 0.73 | LMNA (0.62) | LMNAHPGDKMT2AKDM4ENFE2L2 | |
| SCHEMBL13636009 | 0.72 | SMN1; SMN2 (0.59) | LMNAHPGDKMT2AKDM4ETDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1421071-B1 | SUBSTITUTED PIPERAZINE AND DIAZEPANE DERIVAIVES AS HISTAMINE H3 RECEPTOR MODULATORS | HIGH POINT PHARMACEUTICALS LLC (US) | 2009-11-18 | — | — | EP | disclosed |