Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13636165 | 0.99 | HPGD (0.46) | HPGDKMT2ALMNAMAPTNPC1 | |
| SCHEMBL4386306 | 0.85 | KMT2A (0.60) | HPGDKMT2ALMNAMAPTNPC1 | |
| SCHEMBL14190925 | 0.85 | KMT2A (0.60) | HPGDKMT2ALMNAMAPTNPC1 | |
| SCHEMBL14190940 | 0.84 | KMT2A (0.61) | HPGDKMT2ALMNAMAPTNPC1 | |
| SCHEMBL4382984 | 0.84 | KMT2A (0.61) | HPGDKMT2ALMNAMAPTNPC1 | |
| SCHEMBL13636016 | 0.79 | LMNA (0.44) | HPGDKMT2ALMNAMAPTNPC1 | |
| SCHEMBL2831501 | 0.76 | HPGD (0.61) | HPGDKMT2ALMNAMAPTNPC1 | |
| SCHEMBL4382018 | 0.76 | HCAR2 (0.48) | HPGDKMT2AMAPTNPC1RAB9A | |
| SCHEMBL14190928 | 0.76 | HCAR2 (0.48) | HPGDKMT2AMAPTNPC1RAB9A | |
| SCHEMBL3769345 | 0.75 | L3MBTL1 (0.53) | HPGDKMT2ALMNAMAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1421071-B1 | SUBSTITUTED PIPERAZINE AND DIAZEPANE DERIVAIVES AS HISTAMINE H3 RECEPTOR MODULATORS | HIGH POINT PHARMACEUTICALS LLC (US) | 2009-11-18 | — | — | EP | disclosed |