Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 14/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13635939 | 0.91 | HSD11B1 (0.69) | HSD11B1CYP3A4 | |
| SCHEMBL13636065 | 0.91 | HSD11B1 (0.69) | HSD11B1CYP3A4 | |
| SCHEMBL13636043 | 0.86 | HSD11B1 (0.68) | HSD11B1CYP3A4 | |
| SCHEMBL13635932 | 0.85 | HSD11B1 (0.53) | HSD11B1CYP3A4 | |
| SCHEMBL13635936 | 0.82 | HSD11B1 (0.56) | HSD11B1CYP3A4 | |
| SCHEMBL4369415 | 0.82 | HSD11B1 (0.83) | HSD11B1CYP3A4 | |
| SCHEMBL13636081 | 0.81 | HSD11B1 (0.55) | HSD11B1CYP3A4 | |
| SCHEMBL13636270 | 0.80 | HSD11B1 (0.53) | HSD11B1CYP3A4 | |
| SCHEMBL13636067 | 0.79 | HSD11B1 (0.47) | HSD11B1CYP3A4KMT2A | |
| SCHEMBL13636287 | 0.78 | HSD11B1 (0.43) | HSD11B1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622492-B2 | Pyrazolones as inhibitors of 11β-hydroxysteroid dehydrogenase | HOFFMANN-LA ROCHE INC. (US) | 2009-11-24 | — | — | US | disclosed |
| US-20070049632-A1 | Pyrazolones as inhibitors of 11B-hydroxysteroid dehydrogenase | BANNER BRUCE L | 2007-03-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070049632-A1 | Pyrazolones as inhibitors of 11B-hydroxysteroid dehydrogenase | HSD17B1, HSD17B2, HSD3B2 | HSD11B1 5/4885CYP3A4 124/4885CNR1 4334/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.