Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.58 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.45 |
| ▸ | IAPP | P10997 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | XDH | P47989 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 3/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | TYR | P14679 | 1/20 | 0.42 |
| ▸ | NAAA | Q02083 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4377253 | 0.81 | KMT2A (0.58) | NPC1RAB9A | |
| SCHEMBL4380739 | 0.81 | TRPV1 (0.58) | NPC1RAB9ATSHRTDP1 | |
| SCHEMBL9345400 | 0.81 | NPC1 (0.61) | NPC1IAPPNAAATDP1 | |
| SCHEMBL9346536 | 0.80 | IAPP (0.53) | NPC1ROCK2IAPPTSHRAPP | |
| SCHEMBL9346942 | 0.80 | MEN1 (0.57) | NPC1TSHRAPPTDP1 | |
| SCHEMBL9350110 | 0.79 | NPC1 (0.59) | NPC1IAPPNAAATDP1 | |
| SCHEMBL13636497 | 0.79 | NPC1 (0.58) | NPC1RAB9ATSHRTDP1 | |
| SCHEMBL4386065 | 0.79 | FKBP1A (0.63) | NPC1RAB9ATSHRAPP | |
| SCHEMBL4377878 | 0.77 | SIGMAR1 (0.61) | NPC1RAB9A | |
| SCHEMBL10483827 | 0.77 | GAA (0.52) | NPC1ROCK2IAPPAPPCYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1421071-B1 | SUBSTITUTED PIPERAZINE AND DIAZEPANE DERIVAIVES AS HISTAMINE H3 RECEPTOR MODULATORS | HIGH POINT PHARMACEUTICALS LLC (US) | 2009-11-18 | — | — | EP | disclosed |