Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 3/20 | 0.57 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 11/20 | 0.49 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.46 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1177322 | 0.99 | EPHX2 (0.56) | EPHX2MAPK10MEN1CYP1A2CYP2C9 | |
| SCHEMBL13636465 | 0.85 | EPHX2 (0.53) | EPHX2MAPK10HRH3SLC6A4 | |
| SCHEMBL13636419 | 0.85 | CHRNA7 (0.56) | MAPK10HRH3BDKRB1SLC6A4 | |
| Hydrochloric Acid SCHEMBL1177307 | 0.84 | EPHX2 (0.53) | EPHX2MAPK10HRH3SLC6A4 | |
| SCHEMBL1177142 | 0.84 | EPHX2 (0.72) | EPHX2MAPK10HRH3SLC6A4 | |
| Hydrochloric Acid SCHEMBL1177765 | 0.84 | CHRNA7 (0.55) | MAPK10HRH3BDKRB1SLC6A4 | |
| SCHEMBL1177760 | 0.80 | HRH3 (0.58) | MAPK10CYP1A2CYP2C9CYP2C19HRH3 | |
| SCHEMBL14088954 | 0.80 | EPHX2 (0.54) | EPHX2MAPK10HRH3SCN9A | |
| Hydrochloric Acid SCHEMBL1177061 | 0.79 | EPHX2 (0.53) | EPHX2MAPK10HRH3SCN9A | |
| SCHEMBL13503647 | 0.79 | EPHX2 (0.81) | EPHX2MEN1KMT2AHRH3SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1558595-B1 | PIPERAZINYL AND DIAZAPANYL BENZAMIDES AND BENZTHIOAMIDES | JANSSEN PHARMACEUTICA NV (BE) | 2009-11-25 | — | — | EP | disclosed |
| US-7414047-B2 | Piperazinyl and diazapanyl benzamides and benzthioamides | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-08-19 | — | — | US | disclosed |
| US-7414047-B2 | Piperazinyl and diazapanyl benzamides and benzthioamides | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-08-19 | — | — | US | disclosed |
| US-20080056991-A1 | PIPERAZINYL AND DIAZAPANYL BENZAMIDES AND BENZTHIOAMIDES | APODACA RICHARD L | 2008-03-06 | — | — | US | disclosed |
| US-20080056991-A1 | PIPERAZINYL AND DIAZAPANYL BENZAMIDES AND BENZTHIOAMIDES | APODACA RICHARD L | 2008-03-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080056991-A1 | PIPERAZINYL AND DIAZAPANYL BENZAMIDES AND BENZTHIOAMIDES | HRH2, HNMT, HRH3 | EPHX2 1050/4885MAPK10 3119/4885MEN1 902/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.