Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 4/20 | 0.72 |
| ▸ | PRKAB2 | O43741 | 4/20 | 0.54 |
| ▸ | PRKAG1 | P54619 | 4/20 | 0.54 |
| ▸ | PRKAA2 | P54646 | 4/20 | 0.54 |
| ▸ | PRKAA1 | Q13131 | 4/20 | 0.54 |
| ▸ | PRKAG3 | Q9UGI9 | 4/20 | 0.54 |
| ▸ | PRKAG2 | Q9UGJ0 | 4/20 | 0.54 |
| ▸ | PRKAB1 | Q9Y478 | 4/20 | 0.54 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.54 |
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.54 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.53 |
| ▸ | CNR1 | P21554 | 1/20 | 0.50 |
| ▸ | CNR2 | P34972 | 1/20 | 0.50 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13636650 | 0.89 | HRH3 (0.60) | EPHX2PRKAB2PRKAG1PRKAA2PRKAA1 | |
| Hydrochloric Acid SCHEMBL1177476 | 0.88 | HRH3 (0.61) | EPHX2PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL13503647 | 0.86 | EPHX2 (0.81) | EPHX2HRH3SLC6A4CNR1CNR2 | |
| SCHEMBL13636423 | 0.85 | HRH3 (0.60) | EPHX2MAPK10HRH3SLC6A4 | |
| SCHEMBL13636334 | 0.84 | EPHX2 (0.57) | EPHX2MAPK10HRH3SLC6A4 | |
| SCHEMBL14088954 | 0.84 | EPHX2 (0.54) | EPHX2MAPK10HRH3 | |
| Hydrochloric Acid SCHEMBL1177561 | 0.84 | HRH3 (0.58) | EPHX2MAPK10HRH3SLC6A4 | |
| SCHEMBL3937867 | 0.84 | EPHX2 (1.00) | EPHX2PRKAB2PRKAG1PRKAA2PRKAA1 | |
| Hydrochloric Acid SCHEMBL1177322 | 0.83 | EPHX2 (0.56) | EPHX2MAPK10HRH3SLC6A4 | |
| Hydrochloric Acid SCHEMBL1177061 | 0.83 | EPHX2 (0.53) | EPHX2MAPK10HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1558595-B1 | PIPERAZINYL AND DIAZAPANYL BENZAMIDES AND BENZTHIOAMIDES | JANSSEN PHARMACEUTICA NV (BE) | 2009-11-25 | — | — | EP | claimed |
| US-20080056991-A1 | PIPERAZINYL AND DIAZAPANYL BENZAMIDES AND BENZTHIOAMIDES | APODACA RICHARD L | 2008-03-06 | — | — | US | claimed |
| CN-1729180-A | Piperazinyl and diazapanyl benzamides and benzthioamides | JANSSEN PHARMACEUTICA NV (BE) | 2006-02-01 | — | — | CN | claimed |
| EP-1558595-A1 | PIPERAZINYL AND DIAZAPANYL BENZAMIDES AND BENZTHIOAMIDES | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-08-03 | — | — | EP | claimed |
| US-20040110746-A1 | Piperazinyl and diazapanyl benzamides and benzthioamides | JANSSEN PHARMACEUTICA N.V. (BE) | 2004-06-10 | — | — | US | claimed |
| WO-2004037801-A1 | PIPERAZINYL AND DIAZAPANYL BENZAMIDES AND BENZTHIOAMIDES | JANSSEN PHARMACEUTICA, N.V. (BE) | 2004-05-06 | — | — | WO | claimed |
| US-8680273-B2 | Process for the preparation of piperazinyl and diazepanyl benzamide derivatives | JANSSEN PHARMACEUTICA NV (BE) | 2014-03-25 | — | — | US | disclosed |
| EP-2404911-A1 | Novel processes for the preparation of piperazinyl and diazapanyl benzamide derivatives | Janssen Pharmaceutica NV (BE) | 2012-01-11 | — | — | EP | disclosed |
| US-20110105752-A1 | PROCESS FOR THE PREPARATION OF PIPERAZINYL AND DIAZEPANYL BENZAMIDE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2011-05-05 | — | — | US | disclosed |
| US-7893257-B2 | Reacting 4-Morpholin-4-ylmethyl-benzoic acid with 1-cyclopropyl-piperazine dihydrochloride producing (4-Cyclopropyl-piperazin-1-yl)-(4-morpholin-4-ylmethyl-phenyl)-methanone; sleep disorders, attention deficit hyperactivity disorders (ADHD), learning and memory disorders | JANSSEN PHARMACEUTICA NV (BE) | 2011-02-22 | — | — | US | disclosed |
| US-20100197689-A1 | NOVEL PROCESSES FOR THE PREPARATION OF PIPERAZINYL AND DIAZAPANYL BENZAMIDE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2010-08-05 | — | — | US | disclosed |
| US-7728129-B2 | Processes for the preparation of piperazinyl and diazapanyl benzamide derivatives | JANSSEN PHARMACEUTICA NV (BE) | 2010-06-01 | — | — | US | disclosed |
| CN-101605767-A | The method for preparing piperazinyl phenyl carboxamides derivatives and Diazesuberane yl-benzamide derivatives | JANSSEN PHARMACEUTICA NV (BE) | 2009-12-16 | — | — | CN | disclosed |
| US-20080056991-A1 | PIPERAZINYL AND DIAZAPANYL BENZAMIDES AND BENZTHIOAMIDES | APODACA RICHARD L | 2008-03-06 | — | — | US | disclosed |
| US-20070197508-A1 | NOVEL PROCESSES FOR THE PREPARATION OF PIPERAZINYL AND DIAZAPANYL BENZAMIDE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-08-23 | — | — | US | disclosed |
| WO-2007053427-A2 | NOVEL PROCESSES FOR THE PREPARATION OF PIPERAZINYL AND DIAZAPANYL BENZAMIDE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-05-10 | — | — | WO | disclosed |
| CN-1729180-A | Piperazinyl and diazapanyl benzamides and benzthioamides | JANSSEN PHARMACEUTICA NV (BE) | 2006-02-01 | — | — | CN | disclosed |
| EP-1558595-A1 | PIPERAZINYL AND DIAZAPANYL BENZAMIDES AND BENZTHIOAMIDES | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-08-03 | — | — | EP | disclosed |
| US-20040110746-A1 | Piperazinyl and diazapanyl benzamides and benzthioamides | JANSSEN PHARMACEUTICA N.V. (BE) | 2004-06-10 | — | — | US | disclosed |
| WO-2004037801-A1 | PIPERAZINYL AND DIAZAPANYL BENZAMIDES AND BENZTHIOAMIDES | JANSSEN PHARMACEUTICA, N.V. (BE) | 2004-05-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070197508-A1 | NOVEL PROCESSES FOR THE PREPARATION OF PIPERAZINYL AND DIAZAPANYL BENZAMIDE DERIVATIVES | HRH2, HRH4, HRH1 | EPHX2 923/4885PRKAB2 1686/4885PRKAG1 1571/4885 |
| US-20080056991-A1 | PIPERAZINYL AND DIAZAPANYL BENZAMIDES AND BENZTHIOAMIDES | HRH2, HNMT, HRH3 | EPHX2 1050/4885PRKAB2 2137/4885PRKAG1 2378/4885 |
| US-20100197689-A1 | NOVEL PROCESSES FOR THE PREPARATION OF PIPERAZINYL AND DIAZAPANYL BENZAMIDE DERIVATIVES | HRH2, HRH4, HRH1 | EPHX2 923/4885PRKAB2 1686/4885PRKAG1 1571/4885 |
| US-20040110746-A1 | Piperazinyl and diazapanyl benzamides and benzthioamides | HRH2, HNMT, HRH3 | EPHX2 1050/4885PRKAB2 2137/4885PRKAG1 2378/4885 |
| US-20110105752-A1 | PROCESS FOR THE PREPARATION OF PIPERAZINYL AND DIAZEPANYL BENZAMIDE DERIVATIVES | HRH4, HRH3, HRH2 | EPHX2 925/4885PRKAB2 1679/4885PRKAG1 1914/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.