Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR183 | P32249 | 8/20 | 0.64 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14190905 | 0.86 | GPR183 (0.67) | GPR183GAAALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL4380512 | 0.86 | GPR183 (0.67) | GPR183GAAALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL13636191 | 0.85 | ALDH1A1 (0.68) | GPR183GAAALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL4377314 | 0.85 | GPR183 (0.85) | GPR183 | |
| SCHEMBL4384170 | 0.85 | ALDH1A1 (0.68) | GPR183GAAALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL13636478 | 0.85 | GPR183 (0.85) | GPR183 | |
| SCHEMBL14190910 | 0.83 | ALDH1A1 (0.67) | GPR183GAAALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL4375408 | 0.83 | ALDH1A1 (0.67) | GPR183GAAALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL14190907 | 0.83 | GPR183 (0.62) | GPR183GAAALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL4383718 | 0.83 | GPR183 (0.62) | GPR183GAAALDH1A1SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1421071-B1 | SUBSTITUTED PIPERAZINE AND DIAZEPANE DERIVAIVES AS HISTAMINE H3 RECEPTOR MODULATORS | HIGH POINT PHARMACEUTICALS LLC (US) | 2009-11-18 | — | — | EP | disclosed |