Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.67 |
| ▸ | MEN1 | O00255 | 3/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.67 |
| ▸ | MAPT | P10636 | 3/20 | 0.67 |
| ▸ | NPC1 | O15118 | 2/20 | 0.67 |
| ▸ | RAB9A | P51151 | 2/20 | 0.67 |
| ▸ | GPR183 | P32249 | 6/20 | 0.66 |
| ▸ | HPGD | P15428 | 2/20 | 0.64 |
| ▸ | GAA | P10253 | 2/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14190910 | 1.00 | ALDH1A1 (0.67) | ALDH1A1SMN1; SMN2MEN1KMT2AMAPT | |
| SCHEMBL4380512 | 0.85 | GPR183 (0.67) | ALDH1A1SMN1; SMN2MEN1KMT2AMAPT | |
| SCHEMBL14190905 | 0.85 | GPR183 (0.67) | ALDH1A1SMN1; SMN2MEN1KMT2AMAPT | |
| SCHEMBL4377314 | 0.84 | GPR183 (0.85) | GPR183 | |
| SCHEMBL4384170 | 0.84 | ALDH1A1 (0.68) | ALDH1A1SMN1; SMN2MEN1KMT2AGPR183 | |
| SCHEMBL13636478 | 0.84 | GPR183 (0.85) | GPR183 | |
| SCHEMBL13636191 | 0.84 | ALDH1A1 (0.68) | ALDH1A1SMN1; SMN2MEN1KMT2AGPR183 | |
| SCHEMBL13636347 | 0.83 | GPR183 (0.64) | ALDH1A1SMN1; SMN2MEN1KMT2AMAPT | |
| SCHEMBL14190907 | 0.82 | GPR183 (0.62) | ALDH1A1SMN1; SMN2MEN1KMT2AMAPT | |
| SCHEMBL4383718 | 0.82 | GPR183 (0.62) | ALDH1A1SMN1; SMN2MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1421071-B1 | SUBSTITUTED PIPERAZINE AND DIAZEPANE DERIVAIVES AS HISTAMINE H3 RECEPTOR MODULATORS | HIGH POINT PHARMACEUTICALS LLC (US) | 2009-11-18 | — | — | EP | claimed |
| EP-1421071-B1 | SUBSTITUTED PIPERAZINE AND DIAZEPANE DERIVAIVES AS HISTAMINE H3 RECEPTOR MODULATORS | HIGH POINT PHARMACEUTICALS LLC (US) | 2009-11-18 | — | — | EP | disclosed |
| US-7208497-B2 | Substituted piperazines and diazepanes | NOVO NORDISK A/S (DK) | 2007-04-24 | — | — | US | disclosed |