Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | PDE3B | Q13370 | 6/20 | 0.48 |
| ▸ | PDE3A | Q14432 | 6/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.47 |
| ▸ | CCR2 | P41597 | 1/20 | 0.47 |
| ▸ | HRH1 | P35367 | 5/20 | 0.47 |
| ▸ | CCR3 | P51677 | 5/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4388621 | 0.99 | HRH3 (0.54) | HRH3KDM4EALDH1A1PDE3BPDE3A | |
| SCHEMBL13636210 | 0.82 | HRH3 (0.49) | HRH3KDM4EALDH1A1PDE3BPDE3A | |
| SCHEMBL4379214 | 0.81 | HRH3 (0.53) | HRH3KDM4EALDH1A1PDE3BPDE3A | |
| Hydrochloric Acid SCHEMBL4375783 | 0.81 | HRH3 (0.54) | HRH3KDM4EALDH1A1PDE3BPDE3A | |
| SCHEMBL14190973 | 0.80 | HRH3 (0.61) | HRH3PDE3BPDE3ASMN1; SMN2HRH1 | |
| Hydrochloric Acid SCHEMBL4388263 | 0.79 | HRH3 (0.62) | HRH3SMN1; SMN2HRH1 | |
| SCHEMBL13636213 | 0.79 | HRH3 (0.54) | HRH3KDM4EALDH1A1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL4383960 | 0.78 | HRH3 (0.56) | HRH3KDM4EALDH1A1 | |
| SCHEMBL2791825 | 0.71 | HCRTR1 (0.51) | HRH3KDM4EALDH1A1SMN1; SMN2POLB | |
| SCHEMBL23097796 | 0.71 | ADAMTS5 (0.50) | KDM4EALDH1A1SMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1421071-B1 | SUBSTITUTED PIPERAZINE AND DIAZEPANE DERIVAIVES AS HISTAMINE H3 RECEPTOR MODULATORS | HIGH POINT PHARMACEUTICALS LLC (US) | 2009-11-18 | — | — | EP | disclosed |
| US-20080113968-A1 | Substituted piperazines and diazepanes | NOVO NORDISK A/S (DK) | 2008-05-15 | — | — | US | disclosed |
| US-20080113968-A1 | Substituted piperazines and diazepanes | NOVO NORDISK A/S (DK) | 2008-05-15 | — | — | US | disclosed |
| US-7208497-B2 | Substituted piperazines and diazepanes | NOVO NORDISK A/S (DK) | 2007-04-24 | — | — | US | disclosed |
| US-7208497-B2 | Substituted piperazines and diazepanes | NOVO NORDISK A/S (DK) | 2007-04-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080113968-A1 | Substituted piperazines and diazepanes | HRH3, HRH4, HRH1 | HRH3 1/4885KDM4E 1567/4885ALDH1A1 1907/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.