Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 5/20 | 0.56 |
| ▸ | CTSS | P25774 | 3/20 | 0.56 |
| ▸ | CTSG | P08311 | 1/20 | 0.54 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | SYK | P43405 | 1/20 | 0.48 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.47 |
| ▸ | CTSL | P07711 | 1/20 | 0.46 |
| ▸ | CTSB | P07858 | 1/20 | 0.46 |
| ▸ | PPARA | Q07869 | 2/20 | 0.46 |
| ▸ | REN | P00797 | 2/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | APP | P05067 | 2/20 | 0.45 |
| ▸ | ACE | P12821 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3493706 | 0.90 | CTSK (0.58) | CTSKCTSSCTSGCTRB1ATM | |
| SCHEMBL825574 | 0.90 | CTSK (0.58) | CTSKCTSSCTSGCTRB1ATM | |
| SCHEMBL7239876 | 0.87 | ATM (0.67) | CTSKCTSSATMSYKKLK5 | |
| SCHEMBL13770955 | 0.87 | ATM (0.67) | CTSKCTSSATMSYKKLK5 | |
| SCHEMBL6896458 | 0.87 | ATM (0.67) | CTSKCTSSATMSYKKLK5 | |
| SCHEMBL7696221 | 0.85 | CTSK (0.59) | CTSKCTSSCTSGCTRB1ATM | |
| SCHEMBL14338698 | 0.85 | CTSK (0.59) | CTSKCTSSCTSGCTRB1ATM | |
| SCHEMBL3842588 | 0.85 | CTSK (0.59) | CTSKCTSSCTSGCTRB1ATM | |
| SCHEMBL8607451 | 0.84 | SYK (0.55) | CTSKCTSSCTRB1ATMSYK | |
| SCHEMBL5477129 | 0.84 | S1PR2 (0.45) | CTSKCTSSREN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0931060-B1 | SUBSTITUTED N- (AMINOIMINOMETHYL OR AMINOMETHYL)PHENYL PROPYL AMIDES | AVENTIS PHARMA INC (US) | 2009-11-25 | — | — | EP | disclosed |