Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 9/20 | 0.36 |
| ▸ | PPARA | Q07869 | 7/20 | 0.36 |
| ▸ | PPARG | P37231 | 5/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.34 |
| ▸ | PDE4A | P27815 | 3/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.34 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13441808 | 0.77 | PPARD (0.41) | PPARDPPARAPPARGPTGDR2TSHR | |
| SCHEMBL13637157 | 0.71 | PPARD (0.47) | PPARDPPARAPPARGPTGDR2TSHR | |
| SCHEMBL13441823 | 0.63 | PPARG (0.51) | PPARDPPARAPPARGMAPTMEN1 | |
| SCHEMBL13441807 | 0.63 | PTGDR2 (0.58) | PPARDPPARAPPARGPTGDR2CYP2C9 | |
| SCHEMBL13637151 | 0.63 | PPARG (0.46) | PPARDPPARAPPARGPTGDR2TSHR | |
| SCHEMBL655820 | 0.61 | ALOX15 (0.65) | PPARDPPARGPTGDR2TSHRHSD17B10 | |
| SCHEMBL13637155 | 0.61 | PTGDR2 (0.61) | PPARDPPARAPPARGPTGDR2CYP2C9 | |
| SCHEMBL13637196 | 0.61 | KDM4E (0.53) | PPARDPPARAPPARGPTGDR2CYP1A2 | |
| Hydrochloric Acid SCHEMBL830710 | 0.60 | ALOX15 (0.63) | PPARDPPARGPTGDR2TSHRHSD17B10 | |
| SCHEMBL13407869 | 0.60 | PPARG (0.42) | PPARDPPARAPPARGTSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622491-B2 | Type 2 diabetes, atherosclerosis, cardiovascular disease, Syndrome X; carboxylic acids with dialkyldiether or thioether linking groups e.g. {4-[3-(2-Benzotriazol-2-yl-4-chloro-phenoxy)-propoxy]-phenyl}-acetic acid and {4-[3-(2-benzotriazol-2-yl-4-thiophen-2-yl-phenoxy)-propoxy]-phenyl}-acetic acid | METABOLEX INC. (US) | 2009-11-24 | — | — | US | disclosed |