Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4F2 | P78329 | 1/20 | 0.40 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 6/20 | 0.38 |
| ▸ | PPARA | Q07869 | 5/20 | 0.38 |
| ▸ | PPARD | Q03181 | 4/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13626046 | 0.90 | ALDH1A1 (0.49) | CYP4F2CYP4A11KDM4ENPC1ALDH1A1 | |
| SCHEMBL3584874 | 0.90 | KMO (0.46) | CYP4F2CYP4A11PPARGPPARAPPARD | |
| SCHEMBL13625916 | 0.87 | KMO (0.47) | CYP4F2CYP4A11PPARGPTGDR2KDM4E | |
| SCHEMBL13637151 | 0.77 | PPARG (0.46) | PPARGPPARAPPARDPTGDR2KDM4E | |
| SCHEMBL24648568 | 0.77 | CYP4F2 (0.48) | CYP4F2CYP4A11PPARGPPARAPPARD | |
| SCHEMBL13626049 | 0.74 | PPARG (0.55) | PPARGPPARAPPARDKDM4ENPC1 | |
| SCHEMBL3579373 | 0.74 | PPARG (0.55) | PPARGPPARAPPARD | |
| SCHEMBL3584162 | 0.71 | PPARD (0.52) | PPARGPPARAPPARDKDM4EALDH1A1 | |
| SCHEMBL13626055 | 0.71 | PPARG (0.52) | PPARGPPARAPPARDKDM4ENPC1 | |
| SCHEMBL24648598 | 0.70 | POLB (0.47) | CYP4F2CYP4A11PPARGPPARAPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622491-B2 | Type 2 diabetes, atherosclerosis, cardiovascular disease, Syndrome X; carboxylic acids with dialkyldiether or thioether linking groups e.g. {4-[3-(2-Benzotriazol-2-yl-4-chloro-phenoxy)-propoxy]-phenyl}-acetic acid and {4-[3-(2-benzotriazol-2-yl-4-thiophen-2-yl-phenoxy)-propoxy]-phenyl}-acetic acid | METABOLEX INC. (US) | 2009-11-24 | — | — | US | disclosed |