Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 2/20 | 0.32 |
| ▸ | HTR2A | P28223 | 2/20 | 0.32 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.32 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | PTGFR | P43088 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27292455 | 0.84 | ALDH1A1 (0.33) | KCNH2POLBPTGS1PTGS2ACHE | |
| SCHEMBL23761622 | 0.83 | TAAR1 (0.36) | KCNH2CRHR1HTR2ASLC6A4 | |
| SCHEMBL12172686 | 0.82 | TSHR (0.39) | POLBPKMPTGS1PTGS2ACHE | |
| SCHEMBL22271746 | 0.82 | TSHR (0.39) | POLBPKMPTGS1PTGS2ACHE | |
| Ammonia Solution, Strong SCHEMBL6001281 | 0.82 | TSHR (0.33) | POLBPKMPTGS1PTGS2ACHE | |
| SCHEMBL2632720 | 0.81 | KCNH2 (0.42) | KCNH2CRHR1PKMHTR2A | |
| SCHEMBL29346005 | 0.80 | HTR2A (0.36) | HTR2ASLC6A4 | |
| SCHEMBL23761213 | 0.77 | MPO (0.40) | TSHR | |
| SCHEMBL19697077 | 0.77 | MC4R (0.42) | KCNH2CRHR1PKMSLC6A4 | |
| SCHEMBL800711 | 0.76 | HRH4 (0.40) | KCNH2POLBPTGS1ACHEHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009137733-A1 | INDOLYLALKYL DERIVATIVES OF PYRIMIDINYLPIPERAZINE AND METABOLITES THEREOF FOR TREATMENT OF ANXIETY, DEPRESSION, AND SEXUAL DYSFUNCTION | FABRE-KRAMER PHARMACEUTICALS, INC. (US) | 2009-11-12 | — | — | WO | disclosed |