Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.38 |
| ▸ | LTB4R | Q15722 | 9/20 | 0.37 |
| ▸ | LTB4R2 | Q9NPC1 | 7/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | PLA2G4A | P47712 | 2/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | PPARD | Q03181 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13637199 | 0.87 | LTB4R (0.42) | PLA2G4BLTB4RLTB4R2MEN1KMT2A | |
| SCHEMBL13637162 | 0.72 | LTB4R (0.40) | PLA2G4BLTB4RLTB4R2PPARGPPARD | |
| SCHEMBL13637279 | 0.69 | PPARD (0.35) | MEN1KMT2AL3MBTL1PPARGPPARD | |
| SCHEMBL11596852 | 0.67 | PLA2G4B (0.56) | PLA2G4BLTB4RLTB4R2MEN1KMT2A | |
| SCHEMBL11684213 | 0.66 | PLA2G4B (0.69) | PLA2G4BLTB4RLTB4R2FFAR1ALDH1A1 | |
| SCHEMBL13441623 | 0.64 | LTB4R (0.46) | PLA2G4BLTB4RLTB4R2MEN1KMT2A | |
| SCHEMBL3468511 | 0.63 | PLA2G4B (0.58) | PLA2G4BLTB4RLTB4R2L3MBTL1FFAR1 | |
| SCHEMBL8219005 | 0.62 | PLA2G4B (0.83) | PLA2G4BALDH1A1LMNA | |
| SCHEMBL3467363 | 0.62 | PLA2G4B (0.60) | PLA2G4BLTB4RLTB4R2FFAR1ALDH1A1 | |
| SCHEMBL4209775 | 0.62 | PLA2G4B (0.60) | PLA2G4BLTB4RLTB4R2FFAR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622491-B2 | Type 2 diabetes, atherosclerosis, cardiovascular disease, Syndrome X; carboxylic acids with dialkyldiether or thioether linking groups e.g. {4-[3-(2-Benzotriazol-2-yl-4-chloro-phenoxy)-propoxy]-phenyl}-acetic acid and {4-[3-(2-benzotriazol-2-yl-4-thiophen-2-yl-phenoxy)-propoxy]-phenyl}-acetic acid | METABOLEX INC. (US) | 2009-11-24 | — | — | US | disclosed |